Children's Oncology Group

🇺🇸United States

Country: 🇺🇸United States

Ownership: -

Employees: -

Market Cap: -

Website

Clinical Trials

DNA Biomarkers in Tissue Samples From Patients With Osteosarcoma

Completed

Conditions: Recurrent Osteosarcoma
Localized Osteosarcoma
Metastatic Osteosarcoma

Interventions: Other: Laboratory Biomarker Analysis

First Posted Date: 2010-08-30

Last Posted Date: 2022-03-28

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 125

Registration Number: NCT01190943

Locations: 🇺🇸
Childrens Oncology Group, Philadelphia, Pennsylvania, United States

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin

Phase 1

Active, not recruiting

Conditions: Regional Neuroblastoma
Ganglioneuroblastoma
Localized Unresectable Neuroblastoma
Stage 4 Neuroblastoma
Localized Resectable Neuroblastoma
Stage 4S Neuroblastoma

Interventions: Radiation: 3-Dimensional Conformal Radiation Therapy
Procedure: Autologous Hematopoietic Stem Cell Transplantation
Drug: Busulfan
Drug: Cisplatin
Drug: Cyclophosphamide
Drug: Doxorubicin Hydrochloride
Drug: Etoposide Phosphate
Radiation: External Beam Radiation Therapy
Procedure: In Vitro-Treated Peripheral Blood Stem Cell Transplantation
Radiation: Intensity-Modulated Radiation Therapy
Radiation: Iobenguane I-131
Drug: Isotretinoin
Other: Laboratory Biomarker Analysis
Drug: Melphalan
Other: Pharmacological Study
Other: Questionnaire Administration
Procedure: Therapeutic Conventional Surgery
Drug: Topotecan Hydrochloride
Drug: Vincristine Sulfate

First Posted Date: 2010-08-04

Last Posted Date: 2024-01-05

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 99

Registration Number: NCT01175356

Locations: 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸
Connecticut Children's Medical Center, Hartford, Connecticut, United States

and more 22 locations

Biomarkers in Young Patients With Neuroblastoma

Completed

Conditions: Neuroblastoma

First Posted Date: 2010-07-26

Last Posted Date: 2016-05-18

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 380

Registration Number: NCT01169376

INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease

Phase 1

Completed

Conditions: Myelodysplastic/Myeloproliferative Neoplasms
Unspecified Childhood Solid Tumor, Protocol Specific
Chronic Myeloproliferative Disorders
Leukemia
Myelodysplastic Syndromes

Interventions: Drug: ruxolitinib phosphate
Other: laboratory biomarker analysis
Other: pharmacological study

First Posted Date: 2010-07-16

Last Posted Date: 2014-10-23

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 49

Registration Number: NCT01164163

Locations: 🇺🇸
UAB Comprehensive Cancer Center, Birmingham, Alabama, United States
🇺🇸
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States
🇺🇸
Children's Hospital of Orange County, Orange, California, United States

and more 21 locations

Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia

Phase 2

Completed

Conditions: Hepatoblastoma
Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Recurrent Osteosarcoma
Recurrent Childhood Acute Lymphoblastic Leukemia
Recurrent Childhood Malignant Germ Cell Tumor
Recurrent Childhood Rhabdomyosarcoma
Previously Treated Childhood Rhabdomyosarcoma
Recurrent Childhood Kidney Neoplasm
Recurrent Childhood Acute Myeloid Leukemia
Recurrent Childhood Soft Tissue Sarcoma

Interventions: Drug: Alisertib
Other: Laboratory Biomarker Analysis
Other: Pharmacological Study

First Posted Date: 2010-07-01

Last Posted Date: 2020-05-13

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 118

Registration Number: NCT01154816

Locations: 🇺🇸
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida, United States
🇺🇸
Miller Children's and Women's Hospital Long Beach, Long Beach, California, United States
🇺🇸
Connecticut Children's Medical Center, Hartford, Connecticut, United States

and more 102 locations

Lestaurtinib With or Without Chemotherapy Agents in Samples From Young Patients With Leukemia

Completed

Conditions: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies

Interventions: Other: laboratory biomarker analysis

First Posted Date: 2010-06-25

Last Posted Date: 2016-05-18

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 18

Registration Number: NCT01150669

Locations: 🇺🇸
Children's Oncology Group, Monrovia, California, United States

Obatoclax Mesylate in Samples From Young Patients With Acute Myeloid Leukemia

Completed

Conditions: Leukemia

First Posted Date: 2010-06-25

Last Posted Date: 2016-05-18

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 50

Registration Number: NCT01150656

Drug Biomarkers in Cell Samples From Patients With Acute Myeloid Leukemia

Completed

Conditions: Leukemia

First Posted Date: 2010-06-24

Last Posted Date: 2015-05-12

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 40

Registration Number: NCT01150058

Collection of Bone Marrow From Donors Treated With or Without Filgrastim

Phase 3

Completed

Conditions: No Evidence of Disease
Healthy Stem Cell Donor

Interventions: Procedure: Bone Marrow Donation
Biological: Filgrastim
Other: Laboratory Biomarker Analysis

First Posted Date: 2010-06-23

Last Posted Date: 2020-02-26

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 13

Registration Number: NCT01149096

Locations: 🇺🇸
Lurie Children's Hospital-Chicago, Chicago, Illinois, United States
🇺🇸
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States
🇺🇸
Riley Hospital for Children, Indianapolis, Indiana, United States

and more 19 locations

Biomarkers in Bone Marrow Samples From Patients With Acute Promyelocytic Leukemia

Completed

Conditions: Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
Childhood Acute Promyelocytic Leukemia (M3)
Adult Acute Myeloid Leukemia
Adult Acute Promyelocytic Leukemia (M3)

Interventions: Other: laboratory biomarker analysis

First Posted Date: 2010-06-17

Last Posted Date: 2015-05-07

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 10

Registration Number: NCT01146223

Locations: 🇺🇸
Children's Oncology Group, Monrovia, California, United States

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