MedPath

Children's Oncology Group

πŸ‡ΊπŸ‡ΈUnited States
Ownership
-
Employees
-
Market Cap
-
Website

Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With an IDH2 Mutation

Phase 2
Active, not recruiting
Conditions
Recurrent Acute Myeloid Leukemia
Refractory Acute Myeloid Leukemia
Interventions
Procedure: Biospecimen Collection
Procedure: Bone Marrow Aspiration
Procedure: Bone Marrow Biopsy
First Posted Date
2019-12-18
Last Posted Date
2025-04-29
Lead Sponsor
Children's Oncology Group
Target Recruit Count
10
Registration Number
NCT04203316
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

Arkansas Children's Hospital, Little Rock, Arkansas, United States

πŸ‡ΊπŸ‡Έ

Children's Hospital Colorado, Aurora, Colorado, United States

and more 25 locations

A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery

Phase 2
Active, not recruiting
Conditions
Recurrent Desmoid Fibromatosis
Desmoid Fibromatosis
Unresectable Desmoid Fibromatosis
Interventions
Procedure: Biospecimen Collection
Procedure: Computed Tomography
Procedure: Echocardiography Test
Procedure: Magnetic Resonance Imaging
Other: Quality-of-Life Assessment
Other: Questionnaire Administration
Procedure: X-Ray Imaging
First Posted Date
2019-12-11
Last Posted Date
2025-05-13
Lead Sponsor
Children's Oncology Group
Target Recruit Count
35
Registration Number
NCT04195399
Locations
πŸ‡ΊπŸ‡Έ

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia, United States

πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

USA Health Strada Patient Care Center, Mobile, Alabama, United States

and more 95 locations

Flotetuzumab for the Treatment of Pediatric Recurrent or Refractory Acute Myeloid Leukemia

Phase 1
Active, not recruiting
Conditions
Recurrent Acute Myeloid Leukemia
Refractory Acute Myeloid Leukemia
Interventions
First Posted Date
2019-11-12
Last Posted Date
2025-01-09
Lead Sponsor
Children's Oncology Group
Target Recruit Count
16
Registration Number
NCT04158739
Locations
πŸ‡ΊπŸ‡Έ

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia, United States

πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

Children's Hospital Los Angeles, Los Angeles, California, United States

and more 16 locations

Inherited Genetic Susceptibility in Langerhans Cell Histiocytosis (LCH)

Active, not recruiting
Conditions
Histiocytosis, Langerhans-Cell
Interventions
Other: Biospecimen Collection
Other: Laboratory Biomarker Analysis
Other: Questionnaire Administration
First Posted Date
2019-09-24
Last Posted Date
2025-03-21
Lead Sponsor
Children's Oncology Group
Target Recruit Count
647
Registration Number
NCT04100408
Locations
πŸ‡ΊπŸ‡Έ

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas, United States

Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors, the StepByStep Study

Phase 3
Active, not recruiting
Conditions
Hematopoietic and Lymphoid Cell Neoplasm
Malignant Solid Neoplasm
Interventions
Other: Educational Intervention
Device: FitBit
Other: Goal Setting
Other: Health Promotion and Education
Other: Media Intervention
Behavioral: Telephone-Based Intervention
First Posted Date
2019-09-13
Last Posted Date
2025-06-26
Lead Sponsor
Children's Oncology Group
Target Recruit Count
384
Registration Number
NCT04089358
Locations
πŸ‡ΊπŸ‡Έ

USA Health Strada Patient Care Center, Mobile, Alabama, United States

πŸ‡ΊπŸ‡Έ

Banner Children's at Desert, Mesa, Arizona, United States

πŸ‡ΊπŸ‡Έ

Kaiser Permanente Downey Medical Center, Downey, California, United States

and more 113 locations

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

Phase 3
Recruiting
Conditions
Testicular Leukemia
B Lymphoblastic Lymphoma
B Acute Lymphoblastic Leukemia
Mixed Phenotype Acute Leukemia
Central Nervous System Leukemia
Interventions
Procedure: Biospecimen Collection
Procedure: Bone Marrow Aspiration
Procedure: Bone Marrow Biopsy
Procedure: Bone Scan
Procedure: Computed Tomography
Procedure: Magnetic Resonance Imaging
Other: Questionnaire Administration
Radiation: Radiation Therapy
Procedure: Positron Emission Tomography
First Posted Date
2019-05-22
Last Posted Date
2025-06-12
Lead Sponsor
Children's Oncology Group
Target Recruit Count
4997
Registration Number
NCT03959085
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

USA Health Strada Patient Care Center, Mobile, Alabama, United States

πŸ‡ΊπŸ‡Έ

Providence Alaska Medical Center, Anchorage, Alaska, United States

and more 226 locations

Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia

Phase 2
Active, not recruiting
Conditions
Central Nervous System Neoplasm
Infantile Fibrosarcoma
Recurrent Acute Leukemia
Refractory Acute Leukemia
Solid Neoplasm
Interventions
First Posted Date
2019-02-08
Last Posted Date
2025-06-11
Lead Sponsor
Children's Oncology Group
Target Recruit Count
31
Registration Number
NCT03834961
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

Arkansas Children's Hospital, Little Rock, Arkansas, United States

πŸ‡ΊπŸ‡Έ

Kaiser Permanente Downey Medical Center, Downey, California, United States

and more 77 locations

Stopping Tyrosine Kinase Inhibitors in Affecting Treatment-Free Remission in Patients With Chronic Phase Chronic Myeloid Leukemia

Phase 2
Active, not recruiting
Conditions
Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive
Interventions
Procedure: Biospecimen Collection
Other: Drug Withdrawn
Other: Quality-of-Life Assessment
Other: Questionnaire Administration
First Posted Date
2019-01-25
Last Posted Date
2025-05-23
Lead Sponsor
Children's Oncology Group
Target Recruit Count
110
Registration Number
NCT03817398
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

USA Health Strada Patient Care Center, Mobile, Alabama, United States

πŸ‡ΊπŸ‡Έ

Banner Children's at Desert, Mesa, Arizona, United States

and more 170 locations

Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma

Phase 2
Active, not recruiting
Conditions
High Risk Neuroblastoma
Refractory Neuroblastoma
Recurrent Neuroblastoma
Interventions
First Posted Date
2019-01-07
Last Posted Date
2025-04-09
Lead Sponsor
Children's Oncology Group
Target Recruit Count
94
Registration Number
NCT03794349
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

Arkansas Children's Hospital, Little Rock, Arkansas, United States

πŸ‡ΊπŸ‡Έ

Kaiser Permanente Downey Medical Center, Downey, California, United States

and more 143 locations

Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)

Phase 1
Completed
Conditions
Lymphoblastic Lymphoma
T-cell Lymphoma
T-cell Leukemia
Acute Leukemia
Recurrent Disease
Leukemia, Lymphocytic
Interventions
First Posted Date
2019-01-03
Last Posted Date
2025-03-21
Lead Sponsor
Children's Oncology Group
Target Recruit Count
12
Registration Number
NCT03792256
Locations
πŸ‡ΊπŸ‡Έ

Children's Hospital of Alabama, Birmingham, Alabama, United States

πŸ‡ΊπŸ‡Έ

Loma Linda University Medical Center, Loma Linda, California, United States

πŸ‡ΊπŸ‡Έ

Children's Hospital of Orange County, Orange, California, United States

and more 16 locations
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