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JANSSEN RESEARCH & DEVELOPMENT, LLC
🇺🇸
United States
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🇺🇸
United States
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Clinical Trials
Related News
Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 (Erdafitinib) in Participants With Advanced Hepatocellular Carcinoma
Phase 1
Completed
Conditions
Carcinoma, Hepatocellular
Interventions
Drug: JNJ-42756493 (erdafitinib)
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First Posted Date
2015-04-20
Last Posted Date
2025-02-03
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
53
Registration Number
NCT02421185
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A Study of a Self-Administered Memory Screening Test With Automated Reporting (SAMSTAR) in Participants With Mild Cognitive Impairment
Completed
Conditions
Mild Cognitive Impairment
Interventions
Other: SAMSTAR
Other: RAVLT
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First Posted Date
2015-04-17
Last Posted Date
2016-07-01
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
153
Registration Number
NCT02419183
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A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
Phase 3
Completed
Conditions
Treatment-resistant Depression
Interventions
Drug: Placebo
Drug: Esketamine
Drug: Duloxetine (Oral Antidepressant)
Drug: Escitalopram (Oral antidepressant)
Drug: Sertraline (Oral Antidepressant)
Drug: Venlafaxine Extended Release (XR) (Oral Antidepressant)
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First Posted Date
2015-04-16
Last Posted Date
2025-04-29
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
236
Registration Number
NCT02418585
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A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
Phase 3
Completed
Conditions
Treatment-resistant Depression
Interventions
Drug: Placebo
Drug: Esketamine
Drug: Duloxetine (Oral Antidepressant)
Drug: Escitalopram (Oral antidepressant)
Drug: Sertraline (Oral Antidepressant)
Drug: Venlafaxine Extended Release (XR) (Oral Antidepressant)
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First Posted Date
2015-04-15
Last Posted Date
2025-04-29
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
346
Registration Number
NCT02417064
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An Efficacy and Safety Proof of Concept Study of Daratumumab in Relapsed/Refractory Mantle Cell Lymphoma, Diffuse Large B-Cell Lymphoma, and Follicular Lymphoma
Phase 2
Terminated
Conditions
Lymphoma, Mantle-Cell
Lymphoma, Large B-Cell, Diffuse
Lymphoma, Follicular
Interventions
Drug: Daratumumab
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First Posted Date
2015-04-10
Last Posted Date
2025-02-04
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
36
Registration Number
NCT02413489
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A Study to Evaluate the Safety and Efficacy of Ustekinumab Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
Phase 3
Completed
Conditions
Colitis, Ulcerative
Inflammatory Bowel Diseases
Interventions
Drug: Ustekinumab IV
Drug: Ustekinumab SC
Drug: Placebo IV
Drug: Placebo SC
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First Posted Date
2015-04-02
Last Posted Date
2025-04-29
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
961
Registration Number
NCT02407236
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An Efficacy and Safety Study of Ustekinumab in Participants With Active Nonradiographic Axial Spondyloarthritis
Phase 3
Terminated
Conditions
Nonradiographic Axial Spondylitis, Ankylosing
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First Posted Date
2015-04-02
Last Posted Date
2019-03-13
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
356
Registration Number
NCT02407223
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An Extension Study to Evaluate the Long-Term Safety and Tolerability of JNJ-54861911 in Participants in the Early Alzheimer's Disease Spectrum
Phase 2
Terminated
Conditions
Alzheimer Disease
Interventions
Drug: JNJ-54861911, 10 mg
Drug: JNJ-54861911, 25 mg
Drug: Placebo
Drug: JNJ-54861911, 5 mg
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First Posted Date
2015-04-01
Last Posted Date
2025-04-29
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
90
Registration Number
NCT02406027
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Pharmacokinetic Study to Evaluate the Effect of a Single Dose of Guselkumab (CNTO 1959) on CYP 450 Enzyme Activities After Subcutaneous Administration in Participants With Psoriasis
Phase 1
Completed
Conditions
Psoriasis
Interventions
Drug: Guselkumab
Drug: Midazolam
Drug: Warfarin
Drug: Omeprazole
Drug: Dextromethorphan
Drug: Caffeine
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First Posted Date
2015-03-25
Last Posted Date
2017-09-20
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
16
Registration Number
NCT02397382
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A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults
Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Ibrutinib (Treatment A) [Reference]
Drug: Ibrutinib (Treatment B)
Drug: Ibrutinib (Treatment D)
Drug: Ibrutinib (Treatment C)
Drug: Ibrutinib (Treatment E)
Drug: Ibrutinib (Treatment F)
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First Posted Date
2015-03-17
Last Posted Date
2015-12-23
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
40
Registration Number
NCT02390609
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