Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery - a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Changes in arachidonic acid induced platelet aggregation as compared to baseline (before extracorporeal circulation)
研究概览
简要总结
This study is planned to investigate the relationship between duration of extracorporeal circulation and the extent of (acquired) platelet dysfunctions in patients undergoing cardiac surgery.
详细描述
Patients undergoing complex cardiac surgery are planned to be included. At several intra- and postoperative measuring point, blood is drawn for multiple electrode aggregometry to investigate ex-vivo platelet aggregation as a surrogate for platelet function.
Transfusion rate of allogenic blood products as well as postoperative blood loss is planned to be recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •duration of extracorporeal circulation > 120 min
排除标准
- •pregnancy
结局指标
主要结局
Changes in arachidonic acid induced platelet aggregation as compared to baseline (before extracorporeal circulation)
时间窗: Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU
Multiple Electrode aggregometry parameters
次要结局
- Changes in Adenosin Diphosphate (ADP) and Thrombin induced platelet aggregation as compared to baseline (before extracorporeal circulation)(Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU)
研究者
Christian F. Weber, MD
Dr. Dr. Christian Friedrich Weber
Goethe University