NCT02792140已完成4 期
The Impact of the Opiate Antagonist Naltrexone on the Emotional Valence of Dreams
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- VAS-difference concerning the emotional valence of dreams
研究概览
简要总结
In this study, the investigators pose the question which influence the opioid circuit has on positive valent situations in dreams.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Written informed consent
- •Healthiness
- •Good capacity of remembering dreams
- •No opiate consumption
排除标准
- •Simultaneous participation in other studies
- •Addictive disorder
- •Abnormal liver function
- •Abnormal kidney function
- •Hypersensitivity to active ingredient or pharmaceutical additives
- •Hereditary galactose intolerance
- •Lactase deficiency
- •Glucose-galactose malabsorption
- •Intake of opioid medication
研究组 & 干预措施
Naltrexone
Experimental
daily administration of 50mg Naltrexone, reporting of dreams
干预措施: Naltrexone (Drug)
Placebo
Placebo Comparator
daily administration of Placebo, reporting of dreams
干预措施: Placebo (Other)
结局指标
主要结局
VAS-difference concerning the emotional valence of dreams
时间窗: 7 days per condition (Naltrexone, Placebo), intermitted by 14 days of washout
Difference between the mean values of emotional valence of dreams reported in the conditions (Naltrexone, Placebo), as captured in VAS \[visual analog scales\] for every dream
次要结局
- Semiquantitative score of emotional valence of dreams(7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout)
- Qualitative score of emotional valence of dreams(7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
The effect of Naltrexone, an Opiate Receptor Antagonist, on capsaicin dose-response in male Healthy volunteers (NORAH)ISRCTN35917266South Manchester University Hospital (UK)20
撤回
2 期
Neurobiology of Opioid Dependence: 4 - 4Opioid-Related DisordersNCT00000195Yale University
撤回
2 期
Neurobiology of Opioid Dependence: 5 - 5Opioid-Related DisordersNCT00000196Yale University
终止
3 期
Naltrexone in Borderline Personality DisorderBorderline Personality DisorderNCT00124839Central Institute of Mental Health, Mannheim48
已完成
1 期
Understanding How Opioids Affect the Experiential and Neural Signatures of Social ExperiencesNaltrexonePlaceboNCT05007561San Diego State University217