Longitudinal Investigation of Brain Blood Flow Changes in Neurosurgical Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- • Longitudinal observation of brain blood flow changes in neurosurgical patients with or without a neurosurgical intervention as compared to a healthy cohort.
研究概览
简要总结
Primary study objective:
• Longitudinal observation of brain blood flow changes in neurosurgical patients with or without a neurosurgical intervention as compared to a healthy cohort.
Secondary study objectives:
- Longitudinal observation of hemodynamic patterns versus structural brain tissue changes in neurosurgical patients.
- Changes in blood flow patterns and structural brain tissue after neurosurgical interventions as compared to a healthy cohort.
- Determining hemodynamic imaging patterns that can be tested as novel imaging markers.
详细描述
Primary study objective:
• to study the longitudinal observation of brain blood flow changes in neurosurgical patients to evaluate the effect of surgical or conservative treatment on the brain structural and hemodynamic integrity.
Secondary study objectives:
- To observe the relationship between longitudinal changes in hemodynamic patterns and structural brain tissue changes in neurosurgical patients.
- To determine different hemodynamic patterns that may be used as novel imaging biomarkers in future studies.
4.2 Outcomes
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
• Longitudinal observation of brain blood flow changes in neurosurgical patients with or without a neurosurgical intervention as compared to a healthy cohort.
时间窗: 5 years
blood flow changes will be assessed with quantitative blood oxygenation-level dependent cerebrovascular reactivity measurements
次要结局
未报告次要终点