ltrasound Guided Repeated Bilateral Transversus Thoracis Muscle Plane Block (TTP) via catheter and postoperative pain in Cardiac Surgery - TTPcat

Turku University Hospital0 个研究点目标入组 120 人开始时间: 2021年2月10日最近更新: 2021年4月26日

适应症

试验速览

暂无简介。

•1.18 - 80 years of age
•2.Scheduled for open cardiac coronary arterial bypass graft (CABG) OR single heart valve surgery that require median sternotomy under general anesthesia
•3.Patients that are estimated to be weaned from mechanical ventilator not later than 8 h after surgery
•4.Patients that are capable of using the patient controlled analgesia device (PCA) after surgery
•5.Written informed consent
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 120
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•1.A previous history of intolerance to the study drug or related compounds and additives
•2.Redo surgery
•3.Combined CABG and heart valve surgery
•4.Endocarditis and/or mediastinitis
•5.Concomitant drug therapy with strong opioids or strong CYP3A4 or CYP2D6 inductor(s) or inhibitor(s) 2 weeks prior to study.
•6.Patients younger than 20 years or older than 80 years.
•7.Body weight < 60 kg
•8.BMI > 35, sleep apnoea, any other sleep disorder or condition that requires treatment with continuous positive airway pressure or automatic positive airway pressure device.
•9.Existing significant liver or kidney disease
•10.History of alcoholism, drug abuse, psychological or other emotional problems that are likely to invalidate informed consent
•11.Cardiac insufficiency, ejection fraction (LVEF) < 30 %
•12.Patients with a diagnosis for neuropathic pain or chronic pain syndrome
•13.Insulin dependent diabetes mellitus with neuropathy
•14.Participating in other clinical trial under TTP study
•15.Donation of blood for 4 weeks prior and during the study

发起方