Minimum Effective Anesthetic Concentration of Supraclavicular Block, Infraclavicular Block, Femoral Nerve Block and Sciatic Nerve Block Via the Popliteal and Parasacral Approach
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 49
- 试验地点
- 1
- 主要终点
- Effective Concentration of Ropivacaine to Produce Surgical Anesthesia in 50% of Population
研究概览
简要总结
This is a dose finding study to identify the minimum effective anesthetic concentration (MEAC) of ropivacaine to produce insensate body parts sufficient for surgery in supraclavicular and infraclavicular approaches to the brachial plexus, parasacral and popliteal approaches to the sciatic nerve, femoral nerve and transversus abdominis plane (TAP) blocks in adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status I to III (patients may be healthy or have systemic disease, but any disease does not pose a constant threat to life, and patients are neither moribund, nor not expected to survive without the operation).
- •Age 18 or above
- •Undergoing elective ambulatory surgery of the upper limb (excluding the shoulder), lower limb (excluding the hip), or lower abdomen with sensory blockade as part of the pain management plan.
排除标准
- •Body mass index of >35 kg/m2 (higher chance of failure)
- •Deformities of the leg (for patients in the parasacral, femoral, and popliteal groups), or the chest or shoulder (for patients in the supraclavicular, infraclavicular, and TAP groups)
- •Preexisting infection at the injection site
- •Existing neurologic disease
- •Allergy to local anesthetic agents
- •Severe respiratory disease
- •Coagulopathy
- •Any other contraindication to the block being considered
- •Patients requiring total motor blockade as well as sensory blockade
研究组 & 干预措施
Ropivacaine
Sequential allocation of ropivacaine concentration depending on the success or failure of surgical anesthesia of the previous patient
干预措施: Ropivacaine concentration (Drug)
结局指标
主要结局
Effective Concentration of Ropivacaine to Produce Surgical Anesthesia in 50% of Population
时间窗: 1 day
The concentration of ropivacaine for each patient's nerve-block injection was determined per protocol.
次要结局
- Number of Patients With Complications(3 days)
研究者
Timothy R Petersen
Research Information Specialist
University of New Mexico