The Staircase Phenomenon and His Implications on Neuromuscular Block Monitoring During General Anesthesia

简要总结

主要结局

次要结局

• Difference in time until recovery of a TOF ratio (TOFr) of 0.9(From administration of neuromuscular blocking drug until spontaneous reversal (up to 4 hours). Time frame is the duration of general anesthesia before, during and after surgery (up to 4 hours).)
• Difference in TOFr 0.9 Normalized(From administration of neuromuscular blocking drug until spontaneous reversal at this specified point (up to 4 hours). Time frame is the duration of general anesthesia before, during and after surgery (up to 4 hours).)
• Difference in time until recovery of 25% of maximum twitch height ot T1 stimulus (DUR25)(From administration of neuromuscular blocking drug until spontaneous reversal at this specified point (up to 4 hours). Time frame is the duration of general anesthesia before, during and after surgery.(up to 4 hours))
• Time between 25% and 75% of maximum twitch height recovery of T1 stimulus(From administration of neuromuscular blocking drug until spontaneous reversal (up to 4 hours). Time frame is the duration of general anesthesia before, during and after surgery (up to 4 hours).)
• Difference between first stimulus of Train-of-Four ratio at baseline(Single measurement of muscle response after calibration procedure at the beginning of data recording after randomization. It is not a time-to-event variable)
• Difference between TOF ratio after stabilization period time(Single measurement after 20 minutes stabilization period after beginning of neuromuscular stimulation.)
• Difference between T1 height after stabilization period of 20 minutes(Single measurement after 20 minutes stabilization period after beginning of neuromuscular stimulation. It is not a time-to-event variable)
• Difference between TOF ratio at baseline time(Single measurement of muscle response after calibration procedure at the beginning of data recording.)
• Monitor Sensitivity difference between groups(Single value no time frame. Sensitivity is internally set by the monitor during calibration (at the beginning of data recording after randomization))
• Monitor Amperage Intensity after calibration difference (milliAmperes, mA)(Single value no time frame. Sensitivity is internally set by the monitor during calibration (at the beginning of data recording after randomization))
• T1/TOFratio relationship difference(Ratio of specified values recorded by the monitor at the beginning of surgery until onset of neuromuscular block (up to 180 seconds) and during spontaneous recovery up to 4 hours until end of anesthesia)