A study to compare the analgesic efficacy of intrathecal bupivacaine alone with intrathecal bupivacaine midazolam combination in patients undergoing elective infra-umbilical surgery

Background:Spinal anesthetic technique is one of the common procedures used for variousinfra umbilical surgeries. Duration of post operative analgesia is one of theimportant concerns while  performing thisprocedure. Several adjuvants have been tried along with local anesthetic forprolonging the duration of analgesia. In this study we have observed the effectof midazolam as an adjuvant in patients undergoing infra umbilical surgery.

Settingsand Design: A prospective, randomized, double blinded, parallel group, placebocontrolled, open label study tertiary care hospital.

Methods:90 adult patients aged 18 – 60 years, of American Society of Anaesthesiologists(ASA) status I and II, scheduled for elective infraumbilical surgery, were randomlyallocated in two groups. Each patient in group “B†received bupivacaine 12.5mg along with 0.4 ml of normal salinein the subarachnoid block, and patients of group “BM†received 12.5 mgbupivacaine along with preservative free midazolam 0.4ml (2mg). Duration ofanalgesia was calculated from time of administration of the block torequirement of rescue analgesic as demanded by the patient in the postoperative period.

Statisticalanalysis: SPSS v17.0 was used for analysis of data. A p-value < 0.05 wasconsidered statistically significant.

Results& conclusion: Use of midazolam as adjuvant with the local anestheticsignificantly increases the duration of analgesia and motor block but a lessPONV.