Exercise-Induced Metabolic Compensation; a Physiological Adaptive Response to Exercise Training
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- To examine long-term changes in the volume of highly metabolic organs (brain, liver, and kidneys) as an adaptive metabolic response to exercise training
研究概览
简要总结
The primary aim of this proposal is to identify changes in the volume of highly metabolic organs (liver, kidneys, and brain) that occur as a physiological adaptation to exercise training and lower the resting energy expenditure. Secondary aims are to identify changes in the metabolic efficiency of muscle in low levels of physical activity and evaluate the effects on components of total daily energy expenditure including the sleeping metabolic rate (SMR) and diet induced thermogenesis (DIT).
详细描述
Using a clinical trial type protocol, 16 overweight (body mass index: 25-30 kg/m2) men (n=8) and women (n=8) aged 21 to 45 years will exercise for 3 months in a moderate intensity regimen of 20 kcal/week/kg body weight that reflects current recommendations for weight management. The volume of various organs will be measured pre- and post-exercise intervention using magnetic resonance imaging (MRI). A cycling ergometer with a varied workload will be used to assess muscle metabolic efficiency. Changes in overnight SMR and 4 hours post breakfast DIT will be evaluated by whole human room indirect calorimetry ("metabolic chamber"). In addition, free-living Total Energy Expenditure (TEE) will be measured for ten days pre- and post-intervention by doubly labeled water.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overweight [body mass index (BMI) 25-30
排除标准
- •Participation in another exercise or weight loss program in the last 6 months
- •Non-stable weight (>±5%) over the past 6 months
- •Current regular exercise > 1 hour per week
- •Smoking within the past 6 months
- •Being post-menopausal, breastfeeding, pregnancy, or having been pregnant within the past 6 months
- •Previous bariatric surgery
- •Cardiopulmonary disease (e.g., recent myocardial infarction or unstable angina)
- •Musculoskeletal or neuromuscular impairments that preclude exercise training
- •Having other health issues include cancer, diabetes, thyroid disease, hypertension, chronic renal failure, cognitive impairments
- •Use of drugs that potentially impact body metabolism.
研究组 & 干预措施
Intervention
Exercise in moderate intensity tailored individually to 20 kcal/kg/week (range 1500-2000 kcal/week) with a free choice to exercise at home/gym on a treadmill or outdoors.
干预措施: Exercise training (Behavioral)
结局指标
主要结局
To examine long-term changes in the volume of highly metabolic organs (brain, liver, and kidneys) as an adaptive metabolic response to exercise training
时间窗: Pre- and post 12 weeks of exercise intervention
The volume of various organs will be measured using magnetic resonance imaging (MRI).
次要结局
- To evaluate the changes in skeletal muscle metabolic efficiency during non- exercise physical activity as an adaptive response to long-term exercise training(Pre- and post 12 weeks of exercise intervention)
- To determine the effect of long-term exercise training on changes in sleeping metabolic rate as an adaptive response .(Pre- and post 12 weeks of exercise intervention)
- To assess the effect of long-term exercise training on changes in diet induced thermogenesis as an adaptive response.(Pre- and post 12 weeks of exercise intervention)
研究者
Gepner Yftach
Principal investigator
Tel Aviv University