NCT01681758已完成2 期
A Before-and-after Assessment of Pulse Pressure Variation Guided Fluid Therapy in Cardiac Surgery Patients Receiving Mandatory Mechanical Ventilation
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 2
- 主要终点
- Mean amount of fluid given in the first 24 hours after surgery
研究概览
简要总结
We aim to test the hypothesis that fluid therapy based on pulse pressure variation (PPV) in patients after cardiac surgery who are mechanically ventilated leads to a significant decrease in the amount of fluid given to such patients in the first 24 hours after surgery
详细描述
- The investigators will study patients after cardiac surgery
- The investigators will collect data on standard care in pre-intervention population
- The investigators will collect demographic and clinical data
- The investigators will collect biochemical data in the first 24 hours after surgery
- The investigators will collect biochemical, physiological and clinical outcome data
- The investigators will compare the standard care and intervention period data
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •immediately after ICU admission after cardiac surgery
- •mandatory mechanical ventilation -
排除标准
- •Pressure support ventilation
- •Intra-aortic balloon counterpulsation
结局指标
主要结局
Mean amount of fluid given in the first 24 hours after surgery
时间窗: 24 hours
all intravenous fluid administered
次要结局
- Physiological outcome(24 hours)
研究者
Rinaldo Bellomo
Director of ICU Research
Austin Health
研究点 (2)
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