Chronic Effects of Fats on Satiety and Energy Expenditure
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 1
- 试验地点
- 2
- 主要终点
- Acute effect of fat intake on energy expenditure as determined by metabolic rate
研究概览
简要总结
The purpose of this study is to evaluate the effect of dietary fat on satiety (the experience of fullness between one meal and the next) and energy metabolism over an extended period of time (chronic effects). How dietary fat sources affect satiety, appetite and energy use is unclear. The investigators will use a controlled setting for the studies. They want to know if the source of dietary fat alters satiety, satiety hormones, and energy expenditure responses after consuming different diets.
详细描述
This work will address the interaction of obesity and dietary fatty acids in regulating satiety and energy metabolism. The primary objective is to determine the effects of chronic intake of dietary fatty acids of varied saturation and chain length on satiety, thermogenesis and energy utilization in healthy individuals. The investigators hypothesize that unsaturated fatty acids will 1) increase satiety and 2) increase energy metabolism and that 3) the fatty acid binding protein polymorphisms are associated with reduced energy expenditure in response to dietary fat intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •body mass index between 25.0-34.9 kg/m2
- •free of major diagnosed, untreated medical conditions
- •non-smoking or use of other tobacco products, including e-cigarettes
- •not taking steroid-based medications
- •not planning to or currently attempting to gain or lose weight
- •willing to comply with study demands
- •low intake of long chain omega-3 fatty acids (<0.10 g/d) or willing to reduce intake for 6 weeks prior to starting the study
排除标准
- •diagnosed eating disorders
- •diabetes (blood sugar ≥ 126 mg/dl)
- •hypertension (systolic > 160 mmHg or diastolic > 100 mmHg)
- •diagnosed cardiovascular, pulmonary, skeletal and metabolic diseases
- •currently pregnant or planning to become pregnant, or lactating
- •taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)
结局指标
主要结局
Acute effect of fat intake on energy expenditure as determined by metabolic rate
时间窗: Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours
次要结局
未报告次要终点