The Effect of Exogenous Ketone Monoester Supplement on Glycemic Response to an Oral Glucose Tolerance Test
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Glucose area under the curve
研究概览
简要总结
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to an oral glucose tolerance test in individuals with impaired fasting glucose.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Placebo masked with flavouring and participants consume in opaque containers
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Not taking any medications affecting glucose metabolism.
- •Elevated fasting glucose level (5.6-6.9 mmol/L) OR body mass index >28 kg/m2 OR elevated waist circumference (>102 cm for males, >88 cm for females)
排除标准
- •Diagnosed with diabetes.
- •Diagnosed with heart disease.
- •Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)
- •Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet
- •Current consumption of ketone supplements
- •Pregnant or planning to become pregnant during the study (if female)
研究组 & 干预措施
Ketone monoester
Acute morning dose of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (0.45 ml/kg body weight)
干预措施: Ketone monoester (Dietary Supplement)
Placebo
Acute morning dose of flavour-matched placebo.
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Glucose area under the curve
时间窗: 2-hour
Area under the curve for glucose during oral glucose tolerance test
次要结局
- Free fatty acids area under the curve(2-hour)
- Insulin incremental area under the curve(2-hour)
- Insulin area under the curve(2-hour)
- Inflammatory cytokines(15 minutes)
- C-peptide area under the curve(2-hour)
- GLP-1 area under the curve(2-hour)
- Glucagon area under the curve(2-hour)
- Glucose incremental area under the curve(2-hour)
- 2-hr glucose level(2-hour)
- Caspase-1 activation(15 minutes)
- Oral glucose sensitivity index(2-hour)
研究者
Jonathan Little
Assistant Professor
University of British Columbia