Mechanism of Action of Electroconvulsive Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Changes in Functional Connectivity of Key Nodes
研究概览
简要总结
This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.
详细描述
This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar and bipolar depression receiving ECT. Patients will be scanned before and after a full course of ECT and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of ECT at the circuit level (2) to determine the mechanism of action of iatrogenic amnesia caused by ECT at the circuit level (3) to study the use of fcMRI as a state biomarker for depression (4) to study the use of fcMRI as a predictor of response for depression.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and Females Between Ages of 18 and 65
- •Diagnosis of Major Depressive Disorder without Psychotic Features or Bipolar I/II
- •Requiring ECT Treatment as Part of Psychiatric Care
排除标准
- •Comorbid diagnoses of Major Depressive Disorder with Psychotic Features, Schizoaffective Disorder, Schizophrenia or Dementia
- •History of Psychosis
- •Substance Use Disorder (Abuse or Dependence) with Active Use Within Last 6 Months
- •Severe or Unstable Medical Illness
- •Medical Contraindication to Anesthesia or ECT (e.g., Recent Myocardial Infarction)
结局指标
主要结局
Changes in Functional Connectivity of Key Nodes
时间窗: Through Treatment Completion, Average of 2 Months
Measured by Magnetic Resonance Imaging, Key Nodes include Subgenual Cingulate, Dorsal Anterior Cingulate, Nucleus Accumbens, Hippocampus, Amygdala and Dorsolateral Prefrontal Cortex
次要结局
- Changes in Functional Connectivity of Memory Circuits(Through Treatment Completion, Average of 2 Months)
研究者
Joan A Camprodon, MD MPH PhD
Chief of Division of Neuropsychiatry, Director of TMS Clinic, Director of Lab for Neuropsychiatry and Neuromodulation
Massachusetts General Hospital