Regulation of Lipoprotein(a) Metabolism in Humans With Reference to Ethnicity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 325
- 试验地点
- 1
- 主要终点
- Genetic variation of Lp(a) levels in each group
研究概览
简要总结
The purpose of this study is to determine whether lipoprotein(a), also called Lp(a), is a risk factor for cardiovascular (heart) disease. Lipoproteins are tiny particles that circulate in the blood. They contain cholesterol, fat, and protein in varying amounts depending on the body's need. Higher levels of lipoproteins in the blood can cause an increased risk of heart disease.
The investigators believe that by studying the Lp(a) lipoprotein in Caucasians and African Americans, the investigators can assess for genetic variation factors related to cardiovascular (heart) disease. The investigators will be looking at 100 African-American families and 100 Caucasian families to confirm whether a higher Lp(a) level is an indicator of a higher risk for heart disease.
详细描述
During the study visit the research staff will ask about the medical history, perform a brief physical exam, and draw approximately 4 teaspoons of blood of each family member.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Of Caucasian or African descent
- •Families must have 2 natural/biological parents and 2 natural/biological offspring
- •6 years old or older
排除标准
- •Races other than African American or Caucasian
- •Families without 2 natural/biological parents and 2 natural/biological offspring
- •younger that 6 years old
结局指标
主要结局
Genetic variation of Lp(a) levels in each group
时间窗: five years
次要结局
未报告次要终点