Migraine and Endothelial Dysfunction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Endothelial Microparticles
研究概览
简要总结
Recently, there is evidence that endothelial activation and dysfunction are associated with migraine, especially in female migraineurs with aura. Our objectives were to determine whether novel endothelial function markers are altered in female migraineurs with aura compared to age-matched controls.
详细描述
Our objectives were to determine whether novel endothelial function methods and novel markers of endothelial activation are associated with migraine in female migraineurs with aura.
Migraine is an independent risk factor for stroke, especially in young women with aura symptoms. Endothelial dysfunction is a risk factor for cardiovascular diseases. Recent studies suggest that there is a link between migraine with aura and endothelial activation, dysfunction and impaired vascular reactivity.
In this case-control study the investigators examine several novel biomarkers of endothelial function such as endothelial progenitor cells and endothelial microparticles as well as novel methods such as reactive hyperemic peripheral arterial tonometry in female migraineurs with aura and age-matched controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •migraine with aura
- •age < 50
- •female gender
排除标准
- •severe infectious disease
- •cardiovascular disease (stroke, coronary heart disease, myocardial infarction)
- •vasculitis
- •peripheral artery disease
- •diabetes mellitus
- •pregnancy
- •drug abuse
- •medication: statin, anticoagulation, aspirin, clopidogrel
- •intake of triptans <24h
结局指标
主要结局
Endothelial Microparticles
时间窗: baseline
Levels of endothelial microparticlel in the peripheral blood using flow cytometry
次要结局
- Levels of circulating Endothelial Progenitor Cells(baseline)
- Digital pulse volume change(baseline)
研究者
Thomas Liman
MD MSC
Charite University, Berlin, Germany