NCT02740595已完成不适用
The Effects of Electronic Cigarettes on Endothelial Function and Oxidative Stress
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 148
- 试验地点
- 2
- 主要终点
- Flow mediated dilatation (FMD)
研究概览
简要总结
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.
详细描述
Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and undergo a measure of endothelial function called brachial artery flow mediated dilatation (FMD). Additionally, oxidative stress will be measured pre and post exposure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Cardiac disease
- •Respiratory disease
- •Diabetes mellitus
结局指标
主要结局
Flow mediated dilatation (FMD)
时间窗: 10 minutes after exposure
FMD is a measure of endothelial function
Paraoxonse
时间窗: less than 1 hour after exposure
plasma oxidative stress
次要结局
未报告次要终点
研究者
Holly R Middlekauff
Professor of Medicine
University of California, Los Angeles
研究点 (2)
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