Effect of Heated-humidified Circuit on Arterial Oxygenation in Patients Undergoing One-lung Ventilation for Thoracoscopic Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 104
- 主要终点
- Arterial oxygenation
研究概览
简要总结
One-lung ventilation interrupts oxygenation. The effect of heated humidifed breathing circuit on arterial oxygenation during one-lung ventilation has not been investigated. The investigators will investigate the effect of the heated humidifed breathing circuit on oxygenation during one-lung ventilation in patients undergoing thoracoscopic surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologist class I-II
- •Patients scheduled for one-lung ventilation for thoracoscopic surgery
排除标准
- •Severe obstructive or restrictive lung disease
- •Preoperative oxygen supply
- •Preoperative intubated state or under mechanical ventilatory support
- •Baseline arterial partial pressure of oxygen (PaO2) < 70 mmHg
- •Symptomatic coronary or peripheral arterial disease
- •Renal failure
- •Preoperative continuous infusion of inotropes or vasopressor
- •Pregnancy
研究组 & 干预措施
Control
Heated breathing circuit will turned off.
干预措施: Heated and humidified breathing circuit off (Device)
Heat
Heated breathing circuit will be turned on.
干预措施: Heated and humidified breathing circuit on (Device)
结局指标
主要结局
Arterial oxygenation
时间窗: At 30 minutes after one-lung ventilation
Arterial oxygenation (mmHg) will be measured by arterial blood analysis.
次要结局
- Heart rate(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Temperature(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Central venous pressure(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Cardiac index(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Pressure peak(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Pressure plateau(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Arterial oxygenation(At 0, 15, 45, and 60 minutes after one-lung ventilation)
- Arterial carbon dioxide(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Oxygen saturation of arterial blood(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Mean arterial pressure(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Arterial blood acidosis(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
研究者
Hyun-Chang Kim
Assistant professor
Keimyung University Dongsan Medical Center