A comparison and validation study of cough challenge responses evoked using two different bronchial provocation systems

niversity of Manchester0 个研究点目标入组 24 人开始时间: 2021年9月16日最近更新: 2024年7月8日

适应症

试验速览

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•Current inclusion criteria as of 21/06/2024:
•1. Aged =18 years
•2. Normal spirometry (FEV1 and FVC %predicted of =80%)
•3. No current or past history of chronic cough or any other respiratory disease
•4. No current or history of chronic pain, irritable bowel syndrome, psychiatric illness or chronic headaches
•5. No previous experience of performing cough challenges (capsaicin study arm only)
•6. Must cough at least 2 times on a single inhalation of any dose of capsaicin/citric acid during the visit 1 cough challenge
•Previous inclusion criteria:
•1. Aged =18 years
•2. Normal spirometry (FEV1 and FVC %predicted of =80%)
•3. No current or past history of chronic cough or any other respiratory disease
•4. No current or history of chronic pain, irritable bowel syndrome, psychiatric illness or chronic headaches
•5. No previous experience of performing cough challenges
•6. Must cough at least 2 times on a single inhalation of any dose of capsaicin during the visit 1 cough challenge

•Current exclusion criteria as of 21/06/2024:
•1. Current smoker or ex-smoker with >20 pack-year history, and/or <6 months abstinence
•2. Upper respiratory tract infection within the last 4 weeks
•3. Use of ACE inhibitors
•4. Use of anti-depressants
•5. Use of centrally acting medications that may alter the cough reflex e.g. opiates
•6. History of drug or alcohol abuse
•7. Current pregnancy or breastfeeding
•8. Concomitant conditions that may alter cough reflex sensitivity e.g. diabetes mellitus, Parkinson’s disease, cerebrovascular disease
•9. Previous cough challenge experience (only applicable for capsaicin study arm)
•Previous exclusion criteria:
•1. Current smoker or ex-smoker with >20 pack-year history, and/or <6 months abstinence
•2. Upper respiratory tract infection within the last 4 weeks
•3. Use of ACE inhibitors
•4. Use of anti-depressants
•5. Use of centrally acting medications that may alter the cough reflex e.g. opiates
•6. History of drug or alcohol abuse
•7. Current pregnancy or breastfeeding
•8. Concomitant conditions that may alter cough reflex sensitivity e.g. diabetes mellitus, Parkinson’s disease, cerebrovascular disease
•9. Previous cough challenge experience

发起方

niversity of Manchester