Cognitive Flexibility Training for Persistent Pain: Neuroimaging Pilot (COFLEX-i)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 2
- 主要终点
- Changes in resting-state fMRI BOLD signal before and after 5 week cognitive training
研究概览
简要总结
To determine whether a 5-week computer-based cognitive training intervention results in changes in resting-state functional connectivity (rsFC) within the brain networks.
详细描述
This project is a single-center prospective pilot study to assess whether cognitive flexibility training through a Lumosity®-based training module over the course a five week timeframe in patients with chronic hip, knee, and back pain results in detectable changes in resting-state functional connectivity (rsFC). The investigators will explore changes in rsFC particularly within the default mode (DMN), frontoparietal (FPN), and cingulo-opercular (CON) brain networks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults between 18 to 70 years old with chronic hip, knee or back pain for >3 months
- •Documented moderate to severe chronic pain
- •English fluency
- •Access to a computer at home and an email account
排除标准
- •Lack of email/lack of basic computer skills
- •Diagnosed Alzheimer's or documented severe cognitive impairment
- •Severely impaired vision or color blindness
- •Unable to complete cognitive testing
- •An interventional pain procedure within one week prior to enrollment testing
- •Scheduled to undergo a pain procedure during the five weeks of cognitive training
- •Self-reported claustrophobia
- •Contraindication to an MRI scan (i.e. presence of metallic foreign body such as an artificial joint or aneurism clip, implanted pacemaker or spinal cord stimulator)
结局指标
主要结局
Changes in resting-state fMRI BOLD signal before and after 5 week cognitive training
时间窗: 5 weeks
Changes in resting-state fMRI BOLD (blood oxygenation level dependent) signal before and after 5-week cognitive training, within the default mode, frontoparietal, and cingulo-opercular brain networks.
次要结局
- Association between change in resting-state fMRI BOLD signal and the change in NCPT following cognitive training.(5 weeks)
研究者
simon.haroutounian
Assistant Professor of Anesthsiology
Washington University School of Medicine