Correlation Between Various Adipokines and Vascular Inflammation Measured by 18FDG-PET In Healthy Male Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Vascular inflammation in carotid arterial wall, represented as the target-to-background ratio (TBR), using FDG-PET
研究概览
简要总结
The inflammatory state and composition of atherosclerotic plaques are considered the main contributing factors responsible for acute cardiovascular events, rather than the degree of stenosis. Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. Recently, a few clinical studies showed that circulating A-FABP level had a close relation with the development of atherosclerosis in human. Therefore, in the present study, the investigators examined the relationship between circulating A-FABP and vascular inflammation of carotid arteries measured using FDG-PET in healthy male subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male volunteers for visiting routine medical check in our clinic
排除标准
- •History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
- •Hypertension
- •Malignancy
- •Severe renal or hepatic disease
- •Subjects taking medications that might affect inflammation such as NSIAD and statin
结局指标
主要结局
Vascular inflammation in carotid arterial wall, represented as the target-to-background ratio (TBR), using FDG-PET
时间窗: 12 weeks
次要结局
- Circulating serum leptin levels(12weeks)
- Circulating serum adiponectin levels(12 weeks)
- Carotid intima-media thickness levels measured using ultrasonography(12 weeks)
- Circulating serum A-FABP levels(12 weeks)