Exercise in Gulf War Illness (GWI)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- To assess the alterations due to exercise in Gulf War Veterans
研究概览
简要总结
The purpose of this study is to determine if submaximal exercise by bicycle stress tests with pulmonary measurement of VO2MAX plus maximal isometric hand grips on 2 consecutive days causes a higher level of "exertional exhaustion" in GWI compared to healthy veterans (HVets).
详细描述
Subjects sat on upright bicycles for preexercise symptoms, respiratory gases, EKG, and vital sign measurements.
Submaximal exercise began at low resistance with increases every 30 to 60 seconds until 70% predicted heart rate was reached by 5 minutes. Subjects maintained their pace until 25 minutes, then resistance was increased incrementally to increase to 85% predicted heart rate (approximately sufficient to reach anaerobic threshold).
Symptoms, respiratory gases, EKG, and vital signs were measured every 5 minutes, at peak of exercise, and 5 minute intervals after exercise.
The identical exercise protocol was used approximately 24 hr later. Secondary outcomes were assessed by comparisons from before exercise to after the second bicycle exercise stress test.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 38 Years 至 86 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Evidence of military enlistment between August 1, 1990 and July 31, 1991, and deployment for 30 consecutive days to:
- •Persian Gulf waters and adjacent land areas
- •Other global locations
- •U.S. only
- •Status prior to 1990 and 1991:
- •Active duty
- •National Guard
排除标准
- •Current active duty military personnel
- •Any one who was not active duty military personnel between August 1, 1990 and July 31, 1991
- •HIV/AIDS; pregnancy or lactation; potential hepatitis; drug addiction; chronic inflammatory, infectious, or autoimmune medical illnesses not associated with GWI; incarceration; dementia, other cognitive limitation; or reliance on a care-giver in order to respond to the questionnaires and other study tests.
- •Amputations of one or both hands and forearms will be permitted but hand grip tests will not be tested
结局指标
主要结局
To assess the alterations due to exercise in Gulf War Veterans
时间窗: 02/2009-09/2012
Difference in duration of exercise between first and second submaximal bicycle exercise stress test
次要结局
未报告次要终点
研究者
James Baraniuk, MD
Professor of Medicine
Georgetown University