Effect of Transcutaneous Electrical Diaphragmatic Stimulation in Prolonged Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 2
- 主要终点
- breathing frequency
研究概览
简要总结
Muscle atrophy and diaphragm dysfunction are common with prolonged mechanical ventilation (PMV). Electrical stimulation has been shown to be beneficial in severe chronic heart failure and chronic obstructive pulmonary disease. However, its effect on PMV is unclear. This study examined the effects of transcutaneous electrical diaphragmatic stimulation (TEDS) on respiratory muscle strength and weaning outcomes in patients with PMV.
详细描述
Subjects on ventilation for ≥21 days were randomly assigned to TEDS or control groups. The TEDS group received muscle electrical stimulation for 30 min/session/day throughout the intervention. Weaning parameters and respiratory muscle strength (Pimax, Pemax) were assessed. The hospitalization outcome, including weaning rate and length of stay, was followed up until discharge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 20 years;
- •MV for > 6 h/day for > 21 days;
- •medical stability
排除标准
- •acute lung or systemic infection,
- •hemodynamic instability,
- •abdominal distention,
结局指标
主要结局
breathing frequency
时间窗: through study completion, an average of 2 weeks
The pulmonary function as assessed by the measurement of respiratory rate
Pimax
时间窗: through study completion, an average of 2 weeks
The pulmonary function as assessed by the measurement of max inspiratory pressure
Vt
时间窗: through study completion, an average of 2 weeks
The pulmonary function as assessed by the measurement of tidal volume
次要结局
- RCC days(through study completion, an average of 6 weeks)
- weaning rate(through study completion, an average of 6 weeks)
研究者
Chen Yen-Huey
Associate lecture
Chang Gung University