Computer-Based Therapy for Mild Cognitive Impairment
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- The study investigates changes in a neuropsychological assessment battery pre-randomization
研究概览
简要总结
The purpose of this study is to determine the neuropsychological and neurophysiological impacts of a computer-based training program designed to improve the cognitive performance of patients with mild cognitive impairment (MCI).
详细描述
The study is a randomized, double-blind, controlled trial of a computerized, cognitive intervention with three main goals: 1) to assess the magnitude of improvements in memory, language function, and cognitive function following computer training, 2) to investigate the neurophysiological mechanisms underlying such neuropsychological improvements, and 3) to demonstrate the feasibility of using this kind of computer-based therapy in older populations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •65 - 90 years of age 2)Meet definition for MCI including complaints of cognitive decline as indicated by patient report and/or informant report, and corroborated by clinician judgment and, the absence of dementia, defined as impairment of memory and at least one other domain of cognitive function.
- •Fluency in English 4)Willing to meet the time commitment of the study
排除标准
- •Clinically significant cerebrovascular disease
- •Individuals scheduled to begin acetylcholinesterase inhibitor (AChEI) therapy -
结局指标
主要结局
The study investigates changes in a neuropsychological assessment battery pre-randomization
and upon the completion of training.
次要结局
- Early evaluations will be conducted from brain imaging; specifically, date
- obtained via positron emission tomography (PET), magnetoencephalography (MEG),
- electroencephalography (EEG), and functional magnetic resonance imaging (fMRI)
- studies.