Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population (ExAMIN AGE)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 158
- 试验地点
- 2
- 主要终点
- Change of pulse wave velocity (m/s)
研究概览
简要总结
The aims of the study are twofold. In the cross-sectional approach (Part I), the study will be conducted in an older population to assess the association of physical fitness on different parts of the human vascular bed. In the interventional approach (Part II), it aims to investigate whether and to what extent advanced vascular ageing (AVA) in older subjects with increased cardiovascular risk can be reversed by regular walking- based high intensity interval training.
详细描述
In the cross-sectional part the investigators analyze physical fitness, vascular health and further outcomes in a healthy older active, a healthy older sedentary and a obese sedentary group with increased cardiovascular risk. The investigators will analyze large and small artery function, physical fitness and activity as well as inflammatory parameters in these three groups. Here the investigators will investigate the influence of physical activity and inflammatory parameters on the vascular health in different beds.
In the intervention part the older sedentary group with increasing cardiovascular risk (OSR) will be randomized in a control and an intervention group. The intervention group will get a high intensity interval training which is walking based and individual adjusted. The control group will get general lifestyle recommendations. After 12 weeks of training OSR group will be tasted again. The aim of the second part is to assess the effect of high intensity interval training on vascular health and inflammatory parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 50 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •men and women aged 50-79 years
- •Active lifestyle: > 9 MET/week (> 3hours moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2
- •Sedentary lifestyle: ≤ 3 MET/week (≤ 1 hour moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2
- •Sedentary men and women aged 50-79 years with increased cardiovascular risk are allowed to have ≥ one additional cardiovascular risk factor
排除标准
- •History of cardiovascular, pulmonary or chronic inflammatory disease
- •blood pressure ≥ 140/90 mmHg during 24h monitoring
- •current or past smoker (in healthy group)
- •macular degeneration or glaucoma
- •compromising orthopaedic problems
研究组 & 干预措施
healthy older active
only cross-sectional
healthy older sedentary
only cross-sectional
older sedentary at risk
cross-sectional and training or control condition
干预措施: Training or control condition (Other)
结局指标
主要结局
Change of pulse wave velocity (m/s)
时间窗: Change from baseline pulse wave velocity at 12 weeks
Measured at local, central and peripheral site
次要结局
- Change of augmentation index (AIx@75) in %(Change from baseline augmentation index at 12 weeks)
- Change of arteriolar to venular diameter ratio (AVR) in µm(Change from baseline AVR at 12 weeks)
- Change of physical activity in METs per week(Change from baseline physical activity at 12 weeks)
- Change of physical fitness in VO2max(Change from baseline VO2max at 12 weeks)
研究者
Henner Hanssen
Prof. Dr. med. Henner Hanssen
University of Basel