The Effects of Exogenous Ketones on Glucose Tolerance
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Glucose area under the curve
研究概览
简要总结
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to a high carbohydrate mixed meal in young healthy individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Placebo masked with flavouring and participants consume in opaque containers
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Young healthy individuals
- •Not taking any medications affecting glucose metabolism
排除标准
- •Competitive endurance athlete (i.e., train specifically for cycling, triathlon or distance running and compete at a high level)
- •Diagnosed with the chronic medical condition that may impact consumption of carbohydrates or supplements (e.g., diabetes, heart disease)
- •Are currently using medications that may interfere with insulin sensitivity
- •Adhere to a strict high-fat low-carbohydrate or ketogenic diet (within the last 3 months)
- •Are currently using ketone supplements
- •Unable to travel to and from the university in order to make your testing appointments.
- •Unable to follow the controlled diet instructions required for the study.
- •If pregnant or are planning to become pregnant during the study (if female)
结局指标
主要结局
Glucose area under the curve
时间窗: 2-hour
Area under the curve for glucose during high carbohydrate mixed meal tolerance test
次要结局
- Insulin area under the curve(2-hour)
- Glucose incremental area under the curve(2-hour)
- Insulin incremental area under the curve(2-hour)
- Free fatty acids area under the curve(2-hour)
- 2-hr glucose level(2-hour)
- Beta-hydroxybutyrate level(2-hour)
研究者
Jonathan Little
Associate Professor
University of British Columbia