Optimal Effect Site Remifentanil Concentration for Smooth Extubation After Thyroid Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Cough
研究概览
简要总结
The study is aimed at determining the remifentanil effect site concentration suppressing the cough at extubation after surgical thyroidectomy, performed under remifentanil/desflurane based general anesthesia, expressed as median and 95th percentile effective dose.
Possible hemodynamic instability, respiratory depression or prolongation of awakening time are also sought.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
盲法说明
Patient under general anesthesia unaware of the effect site concentration of remifentanil before extubation
入排标准
- 年龄范围
- 18 Years 至 67 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18<age<67
- •6 hrs fasting
- •American society of anesthesiology (ASA) Physical Status I o II
- •Informed consent
排除标准
- •Absence of inclusion criteria
- •Use of cough suppressors, angiotensin converting enzyme-inhibitors, sedatives 4 weeks before surgery
- •Arhythmia, pacemaker or unstable cardiovascular disease
- •Hepatic or renal failure
- •Anticipated difficulty in airways management
- •Chronic obstructive pulmonary disease (COPD), Asthma, increased risk for inhalation, airway infection in the previous 4 weeks;
- •Obesity (BMI >35)
- •Pregnancy
- •Hypersensitivity to drugs administered for the study
研究组 & 干预措施
remifentanil
After skin suture, a predetermined Effect site remifentanil concentration will be achieved. Starting from 1.5 ng/ml in the first patient and increased or decreased by 0.2 ng/ml intervals based on the previous patient response: up if cough present, down otherwise ("Dixon's up and down" method).
干预措施: Remifentanil Effect site concentration (Other)
结局指标
主要结局
Cough
时间窗: 15 minutes after surgery
Any episode of sudden and violent abdominal contraction interrupting normal quite spontaneous or assisted ventilation would be accounted as "cough" and defines non-smooth extubation
次要结局
- Hemodynamics 1(15 minutes after surgery)
- Hemodynamics 2(15 minutes after surgery)
- Respiratory outcome 1(15 minutes after surgery)
- Respiratory outcome 2(15 minutes after surgery)
研究者
Prof. Gabriele Finco
Professor of Anesthesiology and Intensive Care
University of Cagliari