Efficacy of 2% lignocaine combined with dexmedetomidine in comparison with 2% lignocaine with 1:80,000 adrenaline in mandibular third molar surgery : A randomised clinical trial
试验速览
- 阶段
- 2/3 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Onset of Anesthesia
研究概览
简要总结
Title: EFFICACY OF 2% LIGNOCAINE WITHDEXMEDETOMIDINE IN COMPARISON TO2% LIGNOCAINE WITH 1:80,000 ADRENALINE IN MANDIBULAR THIRD MOLAR SURGERY: A RANDOMISED CLINICAL TRIAL
Aim: The aim of the study is to compare the efficacy of 2% plain lignocaine combined with dexmedetomidine and 2% lignocaine with 1:80,000 adrenaline for the removal of mandibular impacted third molars.
Objective: The objective of this study is to assess the efficacy of 2% lignocaine combined with dexmedetomidine in comparison to 2% lignocaine with adrenaline for impacted mandibular third molar surgery with regards to following parameters:
ï¬ Onset of anaesthesia
ï¬ Duration of anaesthesia
ï¬ Post-operative pain
ï¬ Oedema
ï¬ Trismus
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 30.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA I (Healthy patients)
- •Patients with Pederson’s difficulty index score 5-6 (moderately difficult)
- •Patients willing for third molar extraction and participating in the study.
排除标准
- •Impacted third molars associated with acute infections or pathologies.
- •Pregnant and lactating females and patients on oral contraceptives.
- •Medically compromised patients (hypertension, bradycardia, hypotension, sinus disorder, liver disorders, renal impairment and uncontrolled diabetes)
- •Tobacco chewers and smokers.
- •Patients allergic to lignocaine with dexmedetomidine, lignocaine, and adrenaline.
结局指标
主要结局
Onset of Anesthesia
时间窗: 24 hours, 72 hours, 120 hours, 168 hours
Duration of Anesthesia
时间窗: 24 hours, 72 hours, 120 hours, 168 hours
Pain
时间窗: 24 hours, 72 hours, 120 hours, 168 hours
Mouth Opening
时间窗: 24 hours, 72 hours, 120 hours, 168 hours
To study the efficacy of dexmedetomidine combined with 2% lignocaine on:
时间窗: 24 hours, 72 hours, 120 hours, 168 hours
Edema
时间窗: 24 hours, 72 hours, 120 hours, 168 hours
次要结局
- To compare the efficacy of 2% lignocaine combined with dexmedetomidine to 2% lignocaine with 1:80,000 adrenaline(24 hours, 72 hours, 120 hours, 168 hours)