Comparison of 2 aerosolized medicines ( dexmedetomidine and lignocaine) on response to passage of tube in the windpipe during general anesthesia
Not Applicable
Not yet recruiting
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/08/056362
- Lead Sponsor
- Dr Thomas Joseph
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA grade I and II, Elective surgeries under general anaesthesia requiring endotracheal intubation
Exclusion Criteria
1. Anticipated difficult airway
2. Patients with BMI >30kg/m2
3. Patients with known allergy to dexmedetomidine
or lignocaine
4. Patients with cardiovascular and
cerebrovascular diseases
5. Pregnancy
6. Patients with basal heart rate <50/min
7. Patients on beta blockers
8. Patients requiring more than one attempt at
intubation
9. Laryngoscopy and intubation time more than 30
seconds
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the change in hemodynamic parameters which includes Mean arterial pressure Systolic blood pressure Diastolic blood pressure heart rate at different time intervalsTimepoint: T0 Before nebulisation <br/ ><br>Tn After nebulization <br/ ><br>T1 1 min after intubation <br/ ><br>T3 3 min after intubation <br/ ><br>T5 5 min after intubation <br/ ><br>T10 10 min after intubation
- Secondary Outcome Measures
Name Time Method To compare the Rate Pressure Product that is Heart rate multiplied by Systolic blood pressure among the two groups <br/ ><br>To compare any adverse effects like sedation hypotension bradycardia & allergic reactions in the two groups <br/ ><br>Timepoint: Tn After nebulization <br/ ><br>T1 1 min after intubation <br/ ><br>T3 3 min after intubation <br/ ><br>T5 5 min after intubation <br/ ><br>T10 10 min after intubation