Brain-based Prediction of the Dying Duration in Humans After Withdrawal of Life Sustaining Therapies to Inform Donation After Circulatory Death
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 102
- 试验地点
- 11
- 主要终点
- To develop a clinically applicable model to predict dying duration in a cohort of patient eligible for donation after circulatory death
研究概览
简要总结
The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be possible. The tool created should help improve planning for organ donation and provide families and healthcare teams with more accurate information.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Eligible for DCD
排除标准
- •Complete high cervical spinal cord injury (C5 and above)
- •Pacemaker in situ
- •Tracheostomy
研究组 & 干预措施
The study cohort will consist of patients eligible for donation after circulatory determination of
结局指标
主要结局
To develop a clinically applicable model to predict dying duration in a cohort of patient eligible for donation after circulatory death
时间窗: The models will be built to predict death within 30, 60 and 120 minutes
Specifically, we aim at assessing the predictive ability of blood-based brain biomarkers, optic nerve sheet diameter as measured by head computed tomography (CT) scans as a surrogate of intracranial pressure and autonomic dysfunction as reflected by abnormal heart rate variability (HRV) to predict the dying duration.
次要结局
- Comparison of the brain-to-heart model to existing models(The models will be compared for death within 30, 60 and 120 minutes)
研究者
Myp Sekhon
Division Head, UBC Critical Care Medicine
University of British Columbia