NCT03703973Unknown不适用
Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery
Xuzhou Medical University1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2016年8月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- the neuropsychological test to measure cognitive function
研究概览
简要总结
To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-cardiac surgery patients;
- •Age is greater than or equal to 65 years old;
- •Han Nationality, mother tongue is chinese;
- •④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;
- •⑤The Geriatric Depression Scale (GDS) grade 1 or 2;
- •⑥The important function without serious heart, brain, liver, kidney, lung and other organs;
- •The ASA class I or II;
- •The people signed informed consent.
排除标准
- •The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery;
- •Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.
结局指标
主要结局
the neuropsychological test to measure cognitive function
时间窗: within the first 3 years (plus or minus 1 year) after surgery
Mini-Mental score examination [MMSE] used for screening of dementia
时间窗: within the first 3 years (plus or minus 1 year) after surgery
the leukocyte telomere length
时间窗: on the surgery day
次要结局
未报告次要终点
研究者
Han Yuan
Doctor-in-charge of Anesthetist
Xuzhou Medical University
研究点 (1)
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