Efficacy of Nebulized Versus Intravenous Magnesium Sulfate in Treatment of Asthma Exacerbation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 123
- 试验地点
- 1
- 主要终点
- Improving pulmonary function tests as PEFR for asthmatic patients
研究概览
简要总结
A prospective study in Beni-Seuf University Hospital that was conducted on 123 adult patients with acute asthma exacerbations. Patients were classified into group (I): received IV magnesium sulfate, group (II): received nebulized magnesium sulfate, and group (III): control group. Blood pressure, respiratory rate, pulse, peak expiratory flow rate (PEFR) measurement using a peak flowmeter, Fischl index and need for hospitalization in patients with acute bronchial asthma were done for all patients before treatment, immediately after the treatment, "30", and "60" min after treatment.
详细描述
Inclusion criteria :
- adult patients between the ages of 18 and 50 years with acute attack of bronchial asthma
- from both sexes
- Normal renal function
- Normal cardiovascular function
Exclusion criteria:
- Patients were younger than 18 years or older than 50 years.
- Patients suffered from chronic obstructive pulmonary disease, renal disorder and heart failure
All patients were subjected to: complete history taking, blood sampling for serum magnesium measurement (on admission before the initial treatment and after the initial treatment) the patients were randomly separated into 3 equal groups each group consists of 41 patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients between the ages of 18 and 50 years with acute attack of bronchial asthma
- •From both sexes
- •Normal Renal function
- •Normal Cardiovascular function
排除标准
- •Patients were younger than 18 years or older than 50 years.
- •Patients suffered from chronic obstructive pulmonary disease
- •Patidnts suffered from renal disorder
- •Patients with heart failure.
研究组 & 干预措施
IV Magnesium Sulfate
干预措施: Magnesium sulfate (Drug)
Inhaled Magnesium Sulfate
干预措施: Magnesium sulfate (Drug)
Control group
干预措施: Magnesium sulfate (Drug)
结局指标
主要结局
Improving pulmonary function tests as PEFR for asthmatic patients
时间窗: 13 monthes
Prevention of the progression asthma exacerbation for included subjects
次要结局
未报告次要终点
研究者
Raghda R.S. Hussein
Assistant Professor of Clinical Pharmacy
Beni-Suef University