A Comparative Study Between Nitroglycerine Infusion and Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 77
- 试验地点
- 1
- 主要终点
- Intraoperative blood pressure values
研究概览
简要总结
This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.
详细描述
Nitroglycerine is a direct vessel wall vasodilator with more venodilator effect than arterial dilator effect. It is used as an anti-anginal and antihypertensive drug. On the other hand, dexmedetomidine is a highly selective alpha 2 adrenergic agonist with sympatholytic effect. This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cancer patients with controlled hypertension and undergoing surgical procedures under general anesthesia
- •≥ Age 18 years.
排除标准
- •patient refusal
- •patients on Beta blockers
- •kidney or liver function impairment
- •bradycardia, any degree of heart block and severe cardiorespiratory disease
研究组 & 干预措施
Nitroglycerin
data of patients meeting the eligibility criteria and received nitroglycerine infusion will be retrieved from medical records.
干预措施: Nitroglycerin (Drug)
Dexmedetomidine
patients will receive dexmedetomidine bolus dose of 1 mic/kg over 20 minutes followed by intravenous infusion of 0.2-0.7 mic/kg/hr adjusted according to each patient hemodynamic response
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
Intraoperative blood pressure values
时间窗: Intraoperative period
measurements of blood pressure
次要结局
- Intraoperative heart rate values(operative time)
研究者
Walaa Youssef Elsabeeny
Lecturer of Anesthesia and Pain management
National Cancer Institute, Egypt