NCT03823885已完成不适用
E-Cigarettes and Monocytes
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 148
- 试验地点
- 2
- 主要终点
- Cellular Reactive Oxygen Species, units = % fluorescence
研究概览
简要总结
Randomized controlled trial of acute use of electronic cigarette effect on oxidative stress and inflammation.
详细描述
Participants will have an acute e-cig exposure on 2 occasions 1) e-cigarette 2) sham e-cig (empty e-cig) control. Blood will be collected before and after E-cig use and analyzed for biomarkers of inflammation and oxidative stress.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
盲法说明
Code
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Cardiac disease Respiratory disease Diabetes
结局指标
主要结局
Cellular Reactive Oxygen Species, units = % fluorescence
时间窗: within 4 hours of E-cig use
cellular oxidative stress, including cytoplasmic and mitochondrial oxidative stress, in viable cells
次要结局
- CD 14+ Monocyte, units = % of total cells(within 4 hours of e-cig use)
研究者
Holly R Middlekauff
Principal Investigator
University of California, Los Angeles
研究点 (2)
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