How do Small Changes in Hydration Influence Cognition: A Mechanistic Investigation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- Focused attention - Eriksen Flanker Task
研究概览
简要总结
The aim of this study is to determine whether drinking plain water when mildly dehydrated benefits cognitive performance and mood. Volunteers undergo a dehydration protocol designed to result in minor dehydration. While some participants receive two 150ml drinks of water others do not. Differences in cognitive functioning are assessed.
详细描述
As an essential nutrient, an inadequate intake of water has negative consequences: without a source of water death will occur in days. When Benton and Young (2015) reviewed the topic they concluded that in healthy adults, mild dehydration (in the range of a loss of 2% body mass) had been found to adversely influence mood and cognition. However, it is unclear at what degree of hypohydration these effects begin to emerge.
This study was designed to determine whether small changes in hydration, of the level that might occur on a day to day basis, influence cognition and mood. During a dehydration protocol (sitting in a room heated to 30 degrees for four hours) young adult participants receive either drink two 150ml cups of water or nothing. Effects on memory, attention and mood are monitored.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •In good general health i.e. no major health condition such as diabetes
- •BMI < 30
排除标准
- •Not on blood pressure medication or blood thinning medication such as aspirin - No learning difficulty such as dyslexia
- •Gastro-intestinal disease
- •Cholesterol and BP
- •Dyslexic/dyspraxic
- •Depression or history of depression or other psychiatric disorder
研究组 & 干预措施
Drink nothing
Participants will drink nothing during the dehydration protocol
Drink water
Participants will receive two 150ml drinks of water during the dehydration protocol
干预措施: Water (Dietary Supplement)
结局指标
主要结局
Focused attention - Eriksen Flanker Task
时间窗: change from 0 to 180 minutes after the start of the dehydration protocol
The Arrow Flankers test measures the ability to direct attention and ignore peripheral information. Participants are required to indicate whether the middle arrow is pointing to the right or left by pressing the corresponding arrow on the keyboard. Either side of the central arrow are distractors. Both the average reaction times (in milliseconds) and accuracy are recorded. The difference in performance from baseline (before the intervention) is analysed.
Episodic memory - list of 30 words
时间窗: change from 0 to 180 minutes after the start of the dehydration protocol
Participants listen to a list of 30 words presented using a tape recorder. The words are of similar difficulty and matched for the number of syllables and frequency with which they occur in English. The subjects are asked to recall and write down as many words as possible. The difference in the total number of words remembered from baseline (before the intervention) is analysed.
次要结局
- Thirst (Participants rate their thirst)(change from 0 to 180 minutes after the start of the dehydration protocol)