Prevention of Deep Venous Thromboembolism: Effect of Preemptive Analgesic of Femoral Nerve Block in Patients Undergoing Total Knee Arthroplasty
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Serum concentration of inflammatory cytokine
研究概览
简要总结
To investigate whether preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines.
详细描述
Femoral nerve block is an effective analgesic mode in patients after total knee arthroplasty. In recent studies, there has been shown that a large amount of neutrophil elastase release from neutrophils could induce the development of deep venous thromboembolism and femoral nerve block may reduce the incidence of the development of deep venous thromboembolism. In addition, inflammatory cytokines including interleukin-1(IL-1), IL-6, IL-8 and tumor necrosis factor(TNF) were associated with deep venous thromboembolism. Thus, the investigators hypothesised that preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients scheduled for total knee arthroplasty under general anesthesia
排除标准
- •ASA physical status Ⅳ-Ⅴ,
- •psychiatric illness,
- •chronic opioid consumption,
- •patient refusal,
- •coagulopathy,
- •peripheral neurological injury,
- •local anesthesia drug allergy,
- •preoperative existing deep venous thromboembolism.
结局指标
主要结局
Serum concentration of inflammatory cytokine
时间窗: change from baseline at 30min, 60min, 90min after using tourniquet and 12h, 24h,48h after operation
次要结局
- Concentration of related inflammatory factors of deep venous thromboembolism(change from baseline at 30min, 60min, 90min after using tourniquet and 12h, 24h,48h after operation)