Determinants of Adipose Tissue Development and Obesity in Children and Adolescents
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Adipose tissue dysfunction
研究概览
简要总结
In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents. The investigators aim to identify and characterize mechanisms and molecular targets that affect the development of adipose tissue and ensuing obesity in childhood and adolescence.
详细描述
The investigators aim to identify how adipose tissue dysfunction in childhood contributes to the development of obesity and related comorbidities and to characterize factors that play a role in the development of adipose dysfunction in children. The investigators will employ a translational approach which is based on the characterization of adipose tissue biology in samples of children to determine alterations leading to adipose tissue dysfunction. These include assessment of the composition (including BAT), remodeling, function, metabolism and inflammation of adipose tissue as well as the adipokine profile. For the assessment of clinical relevance, these experimental data will then be correlated with the clinical phenotype. Finally, we aim to identify factors responsible for early adipose tissue dysfunction and characterize them for their clinical and functional relevance.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •body weight: 3000 g - 180 kg
- •suitable surgical procedure
- •signed informed consent by the guardians and the study participant, if older 12 years
排除标准
- •severe chronic and inflammatory diseases
- •acute or chronic infections
- •oncological diseases
- •clotting disorders
- •complications during surgical procedure
- •drug treatment
- •nil by mouth
结局指标
主要结局
Adipose tissue dysfunction
时间窗: 10 years
Adipose tissue dysfunction is assessed by evaluation of adipocyte size and number (hypertrophy vs. hyperplasia), adipocyte proliferation and differentiation, (lipid) cellular metabolism, inflammation, gene expression, fibrosis, and others; the association of AT dysfunction with clincial phenotype will be assessed
次要结局
- Presence of brown adipose tissue (BAT)(10 years)
- Inflammation of adipose tissue(10 years)
研究者
Antje Koerner, Prof. Dr. med.
Prof. Dr. med.
University of Leipzig