The Influence of Different Thyroid Autoantibodies on Thyroid Function and Pregnancy Outcome After Assisted Reproductive Technology
试验速览
- 阶段
- 不适用
- 入组人数
- 900
- 试验地点
- 2
- 主要终点
- thyroid fonction
研究概览
简要总结
The influence of thyroid autoantibodies on thyroid function in pregnancy after fertility treatment is not well known.
The objectives of the present study are:
- To monitor the course of thyroid function during pregnancy and to compare between women with and without thyroid autoantibodies.
- Compare pregnancy outcome between women with and without thyroid antibodies
详细描述
Thyroid autoantibodies and / or abnormal thyroid function are associated with fertility problems.
A possible explanation for this is, an influence of thyroid autoantibodies on the functioning of the thyroid gland. It is therefore recommended to check thyroid gland function and for the presence of autoantibodies before pregnancy. In general, 2 types of thyroid autoantibodies are known: anti-thyreoperoxidase autoantibodies and anti-thyroglobulin autoantibodies.
In case of abnormal thyroid function, treatment is sometimes necessary in regards to fertility. The risk of abnormal thyroid function is increased in women with thyroid autoantibodies during pregnancy. Therefore, thyroid function is regularly monitored during pregnancy in women with thyroid antibodies. The influence of thyroid autoantibodies on thyroid function in pregnancy after fertility treatment is not well known.
The objectives of the present study are:
- To monitor the course of thyroid function during pregnancy and to compare between women with and without thyroid autoantibodies.
- Compare pregnancy outcome between women with and without thyroid antibodies
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Factorial
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 36 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •first cycle of assisted reproductive technology with follow up of thyroid function at the Universitair Ziekenhuis Brussel
- •age >= 18 and <= 36 years
- •body mass index between 18 and 35
排除标准
- •Patients with clinical thyroid dysfunction
- •Patients being treated with levothyroxine or antithyroid drugs
- •Patients being treated with glucocorticosteroids
- •Patients undergoing in vitro maturation or preimplantation genetic testing.
- •Poor responders during IVF/ICSI stimulation, using the Bologna criteria
研究组 & 干预措施
Tg AB negative, TPO AB negative
Includes patients without thyroid autoantibodies at start of fertility treatment
干预措施: blood test (Diagnostic Test)
Tg AB negative, TPO AB negative
Includes patients without thyroid autoantibodies at start of fertility treatment
干预措施: follow up treatment outcome (Other)
Tg AB positive, TPO AB negative
Includes patients with only anti-thyroglobuline autoantibodies present and no anti-thyreoperoxydase antibodies at start of fertility treatment.
干预措施: follow up treatment outcome (Other)
Tg AB positive, TPO AB negative
Includes patients with only anti-thyroglobuline autoantibodies present and no anti-thyreoperoxydase antibodies at start of fertility treatment.
干预措施: blood test (Diagnostic Test)
Tg AB positive, TPO AB positive
Includes patients with anti-thyroglobuline autoantibodies and anti-thyreoperoxydase antibodies at start of fertility treatment.
干预措施: blood test (Diagnostic Test)
Tg AB positive, TPO AB positive
Includes patients with anti-thyroglobuline autoantibodies and anti-thyreoperoxydase antibodies at start of fertility treatment.
干预措施: follow up treatment outcome (Other)
结局指标
主要结局
thyroid fonction
时间窗: 12 months
TSH, FT4 evolution during pregnancy
cumulative delivery rate
时间窗: 12 months
live birth delivery after IVF stimulation
次要结局
- miscarriage rate(12 months)
- cumulative pregnancy rate(12 months)
研究者
Valerie Uvin
MD
Universitair Ziekenhuis Brussel