A Randomized Comparative Clinical study to evaluate the effect of Kanchanara Guggulu with Amrutadi Kwatha in the management of Mutraghata with special reference to Benign Prostate Hyperplasia (BPH)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Effect of kanchanar guggulu in the management of mutraghata with special reference to BPH
研究概览
简要总结
Mutraghata is a disease of Mutravaha Srothas in which Avarodha i.e. obstruction to the flow of urine is the main feature. There are many conditions in Mutravaha Srothas where obstruction can be present, one such condition is Vatashtila explained under the heading of Mutraghata by Acharya Sushruta.1
In Vatashtila, Prakupita Apana Vayu located between Shakrunmarg and Basti, produces a glandular like swelling that causes Mutrasanga, Atopa, Vithsanga, Mutraavrodha, these features can be correlated with features of Benign Prostate Hyperplasia.2It is a nodular hyperplasia of prostate gland due to formation of one or more nodules, which leads to hesitancy, dysuria, frequency, urgency, haematuria, retention of urine.3
Benign Prostate Hyperplasia occurs in men over 50 years of age, by the age of 60 years 50 % of men have histological evidence of B.P.H. and 15 % have significant lower urinary tract symptoms, therefore there is an intense and persistent requirement to find a simple, safe and economical treatment for B.P.H.4
Kanchanara Guggulu is mentioned inSharangdhara Samhitain the management of Granthi5and Amrutadi Kwatha is explained in Bhaishajyaratnavali in the management of Vatadi Mutrakricha6.
In Yogratnakara, Mutraghata Chikitsa Adhaya in the context of Samanya Kriya, it is mentioned that bheshaja which are used in the management of Ashamari and Mutrakricha can be used in the Mutraghata Chikista7.
Amrutadi Kwatha ingredients having properties of Medhohara and Vata Kaphahara, Mutral, Rasayana in Karma, where Kanchanara Guggulu’singredients having properties of Vata Kapha Shamaka, Basti Shodhaka ,Granthighna and Mutral.8
By taking the above references the study is undertaken to evaluate the combined effect of Amrutadi Kwatha and Kanchanara Guggulu in the management of Mutraghata with special reference to Benign Prostate Hyperplasia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 50.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- Male
入选标准
- •The cases with features mentioned in International prostate symptoms scoring namely Frequency of urination Intermittency of urination Urgency Straining Weak stream of urine Nocturia Incomplete emptying of bladder Cases of BPH confirmed by USG within mild and moderate grade 30 – 50 grams.
排除标准
- •Ca Prostate and other metastatic and neoplastic conditions Neurological disease of urinary system, Stricture Urethra Patients with Infectious diseases like RVD, HBsAg. Exceeding more than 100ml volume with weight more than 100gm Patient having more than 10cm width x 8cm height x4cm thickness According to I-PPS chart 20-35 scoring is severe are exclude.
结局指标
主要结局
Effect of kanchanar guggulu in the management of mutraghata with special reference to BPH
时间窗: 21th day
次要结局
- To compare the effect of Kanchanara Guggulu and Amrutadi Kwatha in the management of Mutraghata with special reference to BPH(21th days)