Echocardiography and Lung Ultrasound Combined Into a Rapid Cardiothoracic Ultrasound Protocol (CaTUS) for Guiding Decongestive Treartment on a Day-to-day Basis in Patients Hospitalized for Acute Heart Failure With Pulmonary Congestion
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 主要终点
- Number of patients with re-hospitalization or death
研究概览
简要总结
A randomized non-blinded study comparing ultrasound-guided therapy with conventional therapy in acute heart failure patients.
详细描述
Study overview:
The purpose of this study is to evaluate whether ultrasound-guided decongestive therapy, guided by a focused thoracic ultrasound protocol combining echocardiography and lung ultrasound, could result in better decongestion and post-discharge prognosis without lengthening hospitalizations in hospitalized Acute Heart Failure patients.
Primary objectives:
To test whether ultrasound-guided therapy could result in reduced 6-month post-discharge mortality rates or re-hospitalization rates
Secondary objectives:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Only the treating physician on the ward will know which arm the patient belongs to
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Multiple bilateral B-lines as a sign of interstitial syndrome on lung ultrasound
- •Elevated natriuretic peptide level
- •Signs of elevated LVEDP on echocardiography
- •Dyspnea at rest or ortophnea
排除标准
- •eGFR <25ml/min/1.73m2 or on dialysis
- •Altered mental orientation
- •Intubated
- •Mitral stenosis or previous mitral valve procedure
- •Chronic pulmonary parenchymal disease Pregnancy/breastfeeding
- •Prisoners
- •Patient under involuntary treatment
- •Decision on study participation not made within 6 hours after receiving information regarding the study
结局指标
主要结局
Number of patients with re-hospitalization or death
时间窗: 6-months, also 3-months will be analyzed
post-discharge combined endpoint of re-hospitalization for acute heart failure or death due to any cause
Number of patients with re-hospitalization
时间窗: 6-months, also 3-months will be analyzed
Post-discharge re-hospitalization due to acute heart failure
次要结局
- Number of patients with decongestion(during hospitalization)
研究者
Juha Hartikainen
Clinical Professor
Kuopio University Hospital