Doppler-based Renal Resistive Index in Assessing Renal Dysfunction Reversibility in ICU Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 367
- 试验地点
- 5
- 主要终点
- Doppler-based renal resistive index
研究概览
简要总结
Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and remains associated with a dismal prognosis. The diagnosis of AKI relies on functional criteria (oliguria and serum creatinine elevation), which carry several important limitations. Additionally, the investigators lack biomarker that may predict short term renal prognosis.
Doppler-based renal resistive index (RI) measurement is a rapid and noninvasive investigative tool that may hold promise for early AKI detection in ICU patients or in differentiating transient from persistent AKI in selected critically ill patients. Although several studies have suggested adequate performance in predicting short-term reversibility of AKI, most of these studies were performed in limited patient samples. Additionally, a recent study has identified discrepant results regarding its diagnostic performance.
The main objective of this large prospective multicentre study is to assess diagnostic performance of Doppler-based renal resistive index in diagnosing persistent AKI in critically ill patients requiring mechanical ventilation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Sinus rhythm
- •Use of conventional mechanical ventilation
排除标准
- •Refusal: patient, family or trusted person to participate in the study
- •Renal artery stenosis known
- •Severe Chronic Renal Failure (clearance < 30 ml.min-1)
研究组 & 干预措施
ICU patients requiring mechanical ventilation
干预措施: Doppler-based renal (Other)
ICU patients requiring mechanical ventilation
干预措施: blood sample and urine sample (Biological)
结局指标
主要结局
Doppler-based renal resistive index
时间窗: Day 0
Doppler-based renal resistive index in diagnosing persistent AKI in critically ill patients requiring mechanical ventilation
次要结局
- usual urinary indices (Fractional excretion of urea, fractional excretion of sodium, ratio U / P urea ratio U / P creatinine)(Day 0)
- Dosages NGAL plasmatique, NGAL urinaire, IGFBP-7, TIMP-2(Day 3)
- Doppler-based renal resistive index(Day 3)
- Dosages NGAL plasmatique, NGAL urinaire, IGFBP-7, TIMP-2(Day 0)