A Comparative Evaluation of Antimicrobial Efficacy of Octenidine Dihydrochloride with Chlorhexidine and Sodium Hypochlorite as Root Canal Irrigants: A Randomized Controlled Trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Antimicrobial efficacy of Octenidine Dihydrochloride (0.1%) compared to Sodium hypochlorite (2.5%) and Chlorhexidine Digluconate (2%) as a root canal irrigant
研究概览
简要总结
AIM OF THE STUDY
To evaluate and compare the antimicrobial efficacy of 0.1% Octenidine Dihydrochloride compared to 2.5% Sodium Hypochlorite and 2% Chlorhexidine Digluconate as root canal irrigant.
MATERIAL AND METHODS
The study is designed as a prospective, randomized, double blinded clinical trial. 60 patients will be enrolled from the department of Conservative Dentistry and Endodontics who are systemically healthy between the age 15-40 years and fulfilling the inclusion criteria of the study. Patients will be randomly assigned into three groups using systemic random sampling technique.
Group 1: 0.1% Octenidine Dihydrochloride
Group 2: 2% Chlorhexidine Digluconate
Group 3: 2.5% Sodium Hypochlorite
Patients and outcome assessor will be blinded to the groups of the study. Chemo-mechanical preparation will be done till F2 Protaper Gold rotary file. And irrigation will be done using three different solutions according to the groups. Then bacterial samples will be collected using paper points before and after the instrumentation. Then Colony forming count will be done to evaluate the efficacy of the different solutions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 15.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients without any systemic disease
- •Tooth with fully formed root
- •Tooth diagnosed with systemic irreversible pulpitis
- •Tooth which does not show tenderness on percussion
- •Tooth with no periapical lesion.
排除标准
- •Patient with systemic disease and co-morbidities
- •Patient with history of medication(antibiotics) 15 days prior to the procedure
- •Tooth with history of previous endodontic treatment
- •Multirooted tooth 5.Non vital tooth
- •Tooth with root caries
- •Tooth with open apex
- •Tooth showing root resorption
- •Tooth with periapical lesion.
结局指标
主要结局
Antimicrobial efficacy of Octenidine Dihydrochloride (0.1%) compared to Sodium hypochlorite (2.5%) and Chlorhexidine Digluconate (2%) as a root canal irrigant
时间窗: Antimicrobial efficacy of Octenidine Dihydrochloride (0.1%) compared to Sodium hypochlorite (2.5%) and Chlorhexidine Digluconate (2%) as a root canal irrigant at baseline, immediately before the chemomechanical preparation and 1 hour after the chemomechanical preparation
次要结局
- Antimicrobial efficacy of 2.5% Sodium hypochlorite & 2% Chlorhexidine Digluconate(Antimicrobial efficacy of 2.5% Sodium hypochlorite & 2% Chlorhexidine Digluconate at baseline immediately before the chemomechanical preparation & 1 hour after the chemomechanical preparation)
研究者
Sahil Ali
Guru Nanak Institute of Dental Sciences and Research