The Acute Effects of Fitness Drink Formulas Containing 100 mg and 140 mg of Caffeine on Energy Expenditure and Fat Metabolism in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- Change in energy expenditure/substrate oxidation in response to exercise
研究概览
简要总结
The purpose of this investigation was to examine the acute effects of consuming two different fitness drink formulas on the physiological response at rest and to exercise in healthy men and women.
详细描述
Thermogenic fitness drinks containing ~200mg of caffeine have been reported to accelerate the metabolism, increase energy, and consequently promote increased fat oxidation. However, determination of the efficacy of lower caffeine concentrations may provide additional options for individuals with preferences for reduced caffeine intake. Therefore, the aim of this study was to evaluate different fitness drink formulas containing a total of 100mg and 140mg of caffeine on the physiological response at rest and to exercise.
This study utilized a randomized, double-blind, placebo-controlled design. All participants completed three testing visits during which they consumed the placebo, the 100mg caffeine formula, and the 140mg caffeine formula. Blood samples, blood pressure, heart rate, resting energy expenditure, substrate oxidation, and neurocognitive assessments were collected at baseline and repeated 30, 60, and 90 minutes post-ingestion. Immediately following the last cognitive assessment, a maximal graded exercise test with gas analysis was conducted on a cycle ergometer to evaluate physical performance and maximal fat oxidation during exercise as well as the physiological response prior to and following exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Young adult men and women between the ages of 18 and 35 years old.
- •Participant is deemed by the investigator to be healthy and free of any physical limitations determined by physical activity readiness questionnaire (PAR-Q+) and medical and activity history questionnaire (MHQ).
- •Participants will be required to be recreationally-active (defined according to American College of Sports Medicine standards of at least 150 minutes exercise per week and verified by information provided in the MHQ).
- •Participant is willing to abstain from dietary supplementation throughout the duration of the study as indicated in the Informed Consent.
- •Participant understands the study procedures and signs forms providing informed consent to participate in the study.
排除标准
- •Inability to perform physical exercise, as determined by the PAR-Q+.
- •Any "Yes" response in the PAR-Q+.
- •History of hypertension, metabolic, hepatorenal, musculoskeletal, autoimmune or neurological disease, as determined by the MHQ.
- •Regular consumption of greater than 250 mg per day of caffeine
- •Currently taking thyroid, antihyperlipidemic, hypoglycemic, anti-hypertensive or androgenic medications.
- •Taking any other nutritional supplement or performance-enhancing drug (determined from MHQ) that may interfere with the outcome variables of the study.
- •Pregnancy (determined from MHQ).
结局指标
主要结局
Change in energy expenditure/substrate oxidation in response to exercise
时间窗: >90 min post-ingestion (pre/peri/post maximal graded exercise test)
Estimates from gas exchange analysis via indirect calorimetry
Change in resting serum glycerol
时间窗: Baseline, 30, 60, and 90 min post-ingestion
Obtained from blood draw of the superficial forearm vein
Change in oxygen consumption/carbon dioxide production in response to exercise
时间窗: >90 min post-ingestion (pre/peri/post maximal graded exercise test)
Estimates from gas exchange analysis via indirect calorimetry
Change in resting minute ventilation
时间窗: Baseline, 30, 60, and 90 min post-ingestion
Estimates from gas exchange analysis via indirect calorimetry
Change in minute ventilation in response to exercise
时间窗: >90 min post-ingestion (pre/peri/post maximal graded exercise test)
Estimates from gas exchange analysis via indirect calorimetry
Change in resting energy expenditure/substrate oxidation
时间窗: Baseline, 30, 60, and 90 min post-ingestion
Estimates from gas exchange analysis via indirect calorimetry
次要结局
- Change in resting blood pressure response(Baseline, 30, 60, and 90 min post-ingestion)
- Change in heart rate/heart rate variability in response to exercise(>90 min post-ingestion (pre/peri/post maximal graded exercise test))
- Change in Automated Neuropsychological Assessment Metrics (ANAM) screening(Baseline, 30, 60, and 90 min post-ingestion)
- Change in resting heart rate/heart rate variability(Baseline, 30, 60, and 90 min post-ingestion)
- Change in power output(>90 min post-ingestion)