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临床试验/NCT05663281
NCT05663281招募中不适用

Thrombus Imaging and Treatment Analytics in Neurology

Chinese PLA General Hospital1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2022年12月15日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
100
试验地点
1
主要终点
Ischemic Stroke Occurrence

研究概览

简要总结

In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.

详细描述

Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age ≥ 18 years
  • Extracranial and/or intracranial artery occlusion confirmed by angiography
  • Available for magnetic resonance high-resolution vessel wall imaging
  • Written informed consent obtained

排除标准

  • Extracranial and/or intracranial artery mild to moderate stenosis
  • Pregnant women
  • Restenosis or occlusion after artery stenting placement

结局指标

主要结局

Ischemic Stroke Occurrence

时间窗: 1-3 Years

Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging

Rate of Successful Recanalization

时间窗: 1-3 Years

Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization.

次要结局

  • Number of Participants with Adverse Events(1-3 Years)

研究者

发起方
Chinese PLA General Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Jinhao Lyu

Attending physician

Chinese PLA General Hospital

研究点 (1)

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