Thrombus Imaging and Treatment Analytics in Neurology
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Ischemic Stroke Occurrence
研究概览
简要总结
In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.
详细描述
Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Extracranial and/or intracranial artery occlusion confirmed by angiography
- •Available for magnetic resonance high-resolution vessel wall imaging
- •Written informed consent obtained
排除标准
- •Extracranial and/or intracranial artery mild to moderate stenosis
- •Pregnant women
- •Restenosis or occlusion after artery stenting placement
结局指标
主要结局
Ischemic Stroke Occurrence
时间窗: 1-3 Years
Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging
Rate of Successful Recanalization
时间窗: 1-3 Years
Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization.
次要结局
- Number of Participants with Adverse Events(1-3 Years)
研究者
Jinhao Lyu
Attending physician
Chinese PLA General Hospital
