The Role of Sub-clinical Inflammation on the Iron Status of Myanmar Anaemic Adolescent Schoolgirls During Iron and Vitamin A Supplementation
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 402
- 试验地点
- 1
- 主要终点
- Haemoglobin Level
研究概览
简要总结
Anemia and vitamin A deficiency (VAD) are major nutritional problems in the world and also in Myanmar. Both nutrient deficiencies result from interaction of several causal factors, and a better understanding of the etiology to interpret the prevalence and to formulate appropriate measures to reduce these deficiencies is necessary. There is a growing concern on the role of sub-clinical inflammation on the nutritional status indicators during the nutritional status assessment. However, there is lack of information on the role of inflammation on the iron supplementation. The adolescent period is a window of opportunity to improve the preconceptional iron status of the girls and recently gained much attention. The purpose of the study is to understand the role of inflammation on iron and vitamin A status during iron and vitamin A supplementation. The findings will show the extent to which iron supplementation has been hampered by inflammation and to formulate the necessary measures to overcome the interference.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 12 Years 至 19 Years(Child, Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •adolescent girls (age 12-19 years)
- •already experienced menarche
- •anemic girls (Hb<120 g/L)
- •no known illness (apparently healthy)
- •free from haemoglobinopathy
- •No regular consumption of iron and vitamin A supplement during the last 3 months
排除标准
- •subjects with chronic illness
- •subjects with severe anaemia
- •who do not give the consents
结局指标
主要结局
Haemoglobin Level
时间窗: at week 0, week 6 and week12
Haemoglobin level (g/L) measured by cyanmethaemoglobin method
Status of Tissue Iron Store
时间窗: at week 0, week 6 and week12
Tissue iron store was measured by serum ferritin
Status of Cellular Iron Deficiency
时间窗: at week 0, week 6 and week12
Cellular Iron deficiency status is also measured by serum transferrin receptor
次要结局
未报告次要终点
