The investigation about bone metabolism and sarcopenia among chronic hepatitis C patients and the impacts of DAAs combination therapy. - The investigation about bone metabolism and sarcopenia among CHC patients and the impacts of DAAs.

The prevalence of sarcopenia in the cirrhotic patients was significantly higher than that in the noncirrhotic patients. Sarcopenia was diagnosed in 27.5% of the 160 patients with vitamin D deficiency, and 4.5% of the 44 patients without vitamin D deficiency. On multivariate analysis, advanced age, low bodymass index and low serum 25(OH)D3 level were significant independent factors associated with sarcopenia. Serum 25(OH)D3 was positively correlated with grip strength and skeletal muscle mass index.