The effect of L-arginine on brown adipose tissue metabolism in South Asian and white Caucasian subjects - The effect of L-arginine on brown adipose tissue activity

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 22 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

Trial ended prematurely

•- Caucasians and South Asians ethnicity
•- Age: 35-50 years
•- Gender: male
•- BMI: 25-30 kg/m2
•- Plasma glucose levels 2 h after OGTT between 7.8 and 11 mM (e.g. impaired glucose tolerance) or Fasting plasma glucose > 5.5 mM
•- Good general health

•- Type 2 diabetes (determined on basis of oral glucose tolerance test (OGTT))
•- BMI > 30 kg/m2
•- Plasma glucose levels 2 h after OGTT < 7.8 mM or Fasting plasma glucose < 5.5 mM
•- Use of beta-blockers (these inhibit BAT activity) < 1 month before start of study or during study
•- Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
•- Abuse of drugs and/or alcohol
•- Hyperthyroidism or hypothyroidism
•- Creatinine (enzymatic method) < 45 or > 100 *mol/L
•- Participation in earlier research or medical examinations that included PET-CT scanning
•- Psychologically unstable subjects (as judged by the treating medical specialist)
•- Subjects with mental retardation (as judged by the treating medical specialist)
•- Subjects with severe behavior disorders (as judged by the treating medical specialist)
•- Contra-indications MRI (facultative): presence of metallic objects in which the magnetic field can disrupt its function, including pacemaker, insulin pump, neurostimulator, vascular clips, interior hearing device and artificial cardiac valves. Additionally, we will exclude subjects with metallic residues in the eye (posttraumatic), large tattoos and orthopaedic protheses in the field of the camera.

发起方

Medisch Universitair Ziekenhuis Maastricht