Comparison of intravenous Dexmedetomidine with Dexmedetomidine-Dexamethasone combination for prevention of Post-Operative Nausea and Vomiting in adult patients after abdominal surgeries
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Nausea
研究概览
简要总结
This is a prospective and interventional randomised comparative study to compare the effect of IV Dexmedetomidine with IV Dexmedetomidine-Dexamethasone combination with Normal Saline as control in preventing PONV in patients following abdominal surgeries under general anaesthesia using a Numerical Rating Scale in 75 patients of ASA physical status I/II of either gender of 18-60 years of age. The primary outcome measured will be incidence/frequency/severity of Nausea and incidence/frequency of Vomiting at regular time intervals post-op for up to 24 hours. The secondary outcomes measured will be post-op sedation using Ramsay Sedation Scale and post-op pain using Visual Analog Scale.
研究设计
- 研究类型
- Interventional
- 分配方式
- Permuted block randomization, fixed
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA physical status I/II.
- •Patients undergoing abdominal surgeries under general anaesthesia.
排除标准
- •Patients with previous history of post-operative nausea and vomiting, abdominal surgery, cardiovascular or cerebrovascular comorbidities, diabetes mellitus.
- •Patients with history of treatment with antiemetic or glucocorticoids.
- •Patients with BMI>30 kg/m2.
结局指标
主要结局
Nausea
时间窗: End of surgery | 1 hour post-op | 3 hour post-op | 6 hour post-op | 9 hour post-op | 12 hour post-op | 24 hour post-op
Incidence and frequency of vomiting
时间窗: End of surgery | 1 hour post-op | 3 hour post-op | 6 hour post-op | 9 hour post-op | 12 hour post-op | 24 hour post-op
次要结局
- Sedation(End of surgery)
- Pain(End of surgery)