Brain morphology in bipolar twin pairs compared with healthy control twin pairs - Follow up - BrABiT: Brain Anatomy in Bipolar Twins

niversitair Medisch Centrum Utrecht0 个研究点目标入组 220 人开始时间: 待定最近更新: 2024年6月18日

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•1) Part of a monozygotic or dizygotic twin pair
•2) For monozygotic twin pairs at least one twin (MZ concordant and MZ discordant) and for dizygotic twin pairs only one twin (DZ discordant) has a diagnoses (life time):
•- Bipolar Disorder I or Bipolar Disorder II (DSM-IV criteria)
•- For the interview and blood sample: not in a acute (hypo)manic or major depressive episode
•3) Age between 18 and 60 years;Healthy controls:
•1) Part of a monozygotic or same-sex dizygotic twin pair
•2) Matched to patient groups on age, sex and zygosity
•3) Age between 18 and 60 years

•1) No history of drug or alcohol dependency (DSM-IV criteria) for the last half year
•2) No history of Cognitive Disorder (DSM-IV criteria)
•3) No history of serious neurological illness
•4) No severe medical illness
•Healthy controls:
•1) No history of specific axis I psychiatric disorder (DSM-IV criteria), on the basis of a SCID interview (Modules A-G)
•2) No history of axis II personality disorder (DSM-IV criteria), on the basis of SIDP-V
•3) No first degree relative with a history of specific axis I psychiatric disorder (DSM-IV criteria), on the basis of a FIGS interview
•4) No history of serious neurological illness
•5) No severe medical illness
•6) No history of drug or alcohol dependency (DSM-IV criteria) for the last half year

发起方

niversitair Medisch Centrum Utrecht